Ver publicación 

Mostrar el registro sencillo de la publicación

Genetic variants in the SLC16A11 gene are associated with increased BMI and insulin levels in nondiabetic Chilean population

dc.contributor.authorMardones, Lorena
dc.contributor.authorPetermann-Rocha, Fanny
dc.contributor.authorMartínez-Sanguinetti, María Adela
dc.contributor.authorLeiva, Ana M.
dc.contributor.authorTroncoso-Pantoja, Claudia
dc.contributor.authorMartorell, Miquel
dc.contributor.authorLasserre-Laso, Nicole
dc.contributor.authorUlloa, Natalia
dc.contributor.authorPérez-Bravo, Francisco
dc.contributor.authorCelis-Morales, Carlos
dc.contributor.authorVillagrán, Marcelo
dc.date.accessioned2021-12-21T13:11:45Z
dc.date.available2021-12-21T13:11:45Z
dc.date.issued2021
dc.identifier.urihttp://repositorio.ucm.cl/handle/ucm/3648
dc.description.abstractObjective: To study the association of SLC16A11 gene variants with obesity and metabolic markers in nondiabetic Chilean adults. Materials and methods: This cross-sectional study included 263 non-diabetic adults. The genotype of the rs75493593 polymorphism of SLC16A11 gene was performed by real-time PCR. It's association with adiposity markers (body weight, BMI, waist circumference and fat mass percentage), metabolic markers (glucose, insulin, HOMAIR, leptin, total cholesterol, LDLc, HDLc, triglycerides, ALT, GGT and hsCRP) and blood pressure was analyzed by linear regression. Results: The minor allele (T) of the SLC16A11 gene (rs75493593) has a frequency of 29.7% among Chileans. Risk genotypes (GT and TT) were associated with a significant 1.49 mU/l increase in plasmatic insulin for each copy of the minor allele (95% CI: 0.12, 2.87, p < 0.05). This association remained significant after adjusting for socio-demographic variables, physical activity and smoking (1.36 mU/l, 95% CI: 0.16, 2.58 p < 0.05), but was lost when BMI was included as a confounding factor. Higher BMI was also significantly associated with polymorphic genotypes in SLC16A11, independent of socio-demographic variables. Conclusion: The minor allele of the SLC16A11 gene (T) is highly prevalent among Chileans and is associated with increased insulin and BMI in nondiabetic individuals. These findings suggest that the genetic variant in SLC16A11 is not only associated with type 2 diabetes as previously shown in Mexicans, but is also related to early metabolic alterations in healthy subjects that may lead to type 2 diabetes.es_CL
dc.language.isoenes_CL
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
dc.sourceArchives of Endocrinology and Metabolism, 65(3), 305-314es_CL
dc.subjectSLC16A11es_CL
dc.subjectDiabetes mellituses_CL
dc.subjectObesityes_CL
dc.subjectMonocarboxylate transporteres_CL
dc.subjectHyperinsulinemiaes_CL
dc.titleGenetic variants in the SLC16A11 gene are associated with increased BMI and insulin levels in nondiabetic Chilean populationes_CL
dc.typeArticlees_CL
dc.ucm.indexacionScopuses_CL
dc.ucm.indexacionIsies_CL
dc.ucm.indexacionScieloes_CL
dc.ucm.uriwww.scielo.br/j/aem/a/LgbMQdVJc9YxyJhzRWgmKhK/?lang=en#es_CL
dc.ucm.doidoi.org/10.20945/2359-3997000000359es_CL


Ficheros en la publicación

FicherosTamañoFormatoVer

No hay ficheros asociados a esta publicación.

Esta publicación aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo de la publicación

Atribución-NoComercial-SinDerivadas 3.0 Chile
Excepto si se señala otra cosa, la licencia de la publicación se describe como Atribución-NoComercial-SinDerivadas 3.0 Chile