Receptor for advanced glycation end-products axis and coronavirus disease 2019 in inflammatory bowel diseases: A dangerous liaison?

Rojas, Armando; Schneider, Iván; Lindner-Sanhueza, Cristian; González-Bonet, Ileana; Morales, Miguel A.

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dc.contributor.author	Rojas, Armando
dc.contributor.author	Schneider, Iván
dc.contributor.author	Lindner-Sanhueza, Cristian
dc.contributor.author	González-Bonet, Ileana
dc.contributor.author	Morales, Miguel A.
dc.date.accessioned	2022-01-03T18:50:05Z
dc.date.available	2022-01-03T18:50:05Z
dc.date.issued	2021
dc.identifier.uri	http://repositorio.ucm.cl/handle/ucm/3696
dc.description.abstract	Compelling evidence supports the crucial role of the receptor for advanced glycation end-products (RAGE) axis activation in many clinical entities. Since the beginning of the coronavirus disease 2019 pandemic, there is an increasing concern about the risk and handling of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in inflammatory gastrointestinal disorders, such as inflammatory bowel diseases (IBD). However, clinical data raised during pandemic suggests that IBD patients do not have an increased risk of contracting SARS-CoV-2 infection or develop a more severe course of infection. In the present review, we intend to highlight how two potentially important contributors to the inflammatory response to SARS-CoV-2 infection in IBD patients, the RAGE axis activation as well as the cross-talk with the renin-angiotensin system, are dampened by the high expression of soluble forms of both RAGE and the angiotensin-converting enzyme (ACE) 2. The soluble form of RAGE functions as a decoy for its ligands, and soluble ACE2 seems to be an additionally attenuating contributor to RAGE axis activation, particularly by avoiding the transactivation of the RAGE axis that can be produced by the virus-mediated imbalance of the ACE/angiotensin II/angiotensin II receptor type 1 pathway.	es_CL
dc.language.iso	en	es_CL
dc.rights	Atribución-NoComercial-SinDerivadas 3.0 Chile	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/cl/	*
dc.source	World Journal of Gastroenterology, 27(19), 2270-2280	es_CL
dc.subject	COVID-19	es_CL
dc.subject	Inflammatory bowel diseases	es_CL
dc.subject	Advanced glycation	es_CL
dc.subject	Angiotensin-converting enzyme 2	es_CL
dc.subject	Alarmins	es_CL
dc.subject	Receptor for advanced glycation end-products	es_CL
dc.subject	Receptor for advanced glycation end-products axis	es_CL
dc.subject	Inflammation	es_CL
dc.title	Receptor for advanced glycation end-products axis and coronavirus disease 2019 in inflammatory bowel diseases: A dangerous liaison?	es_CL
dc.type	Article	es_CL
dc.ucm.facultad	Facultad de Medicina	es_CL
dc.ucm.indexacion	Scopus	es_CL
dc.ucm.indexacion	Isi	es_CL
dc.ucm.uri	www.wjgnet.com/1007-9327/full/v27/i19/2270.htm	es_CL
dc.ucm.doi	doi.org/10.3748/wjg.v27.i19.2270	es_CL