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Are the effects of DES over? a tragic lesson from the past

dc.contributor.authorZamora-León, Pilar
dc.date.accessioned2022-08-02T15:31:52Z
dc.date.available2022-08-02T15:31:52Z
dc.date.issued2021
dc.identifier.urihttp://repositorio.ucm.cl/handle/ucm/3964
dc.description.abstractDiethylstilbestrol (DES), a transplacental endocrine-disrupting chemical, was prescribed to pregnant women for several decades. The number of women who took DES is hard to know precisely, but it has been estimated that over 10 million people have been exposed around the world. DES was classified in the year 2000 as carcinogenic to humans. The deleterious effects induced by DES are very extensive, such as abnormalities or cancers of the genital tract and breast, neurodevelopmental alterations, problems associated with socio-sexual behavior, and immune, pancreatic and cardiovascular disorders. Not only pregnant women but also their children and grandchildren have been affected. Epigenetic alterations have been detected, and intergenerational effects have been observed. More cohort follow-up studies are needed to establish if DES effects are transgenerational. Even though DES is not currently in use, its effects are still present, and families previously exposed and their later generations deserve the continuity of the research studies.es_CL
dc.language.isoenes_CL
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
dc.sourceInternational Journal of Environmental Research and Public Health, 18(19), 10309es_CL
dc.subjectDESes_CL
dc.subjectDiethylstilbestroles_CL
dc.subjectEndocrine-disrupting chemicales_CL
dc.subjectOffspring outcomeses_CL
dc.subjectPregnancyes_CL
dc.titleAre the effects of DES over? a tragic lesson from the pastes_CL
dc.typeArticlees_CL
dc.ucm.facultadFacultad de Medicinaes_CL
dc.ucm.indexacionScopuses_CL
dc.ucm.indexacionIsies_CL
dc.ucm.doidoi.org/10.3390/ijerph181910309es_CL


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