Rice (Oryza sativa L.) is the main staple food of more than 50% of the world’s population. However, global production may need to increase by more than 70% before 2050 to meet global food requirements despite increasing challenges due to environmental degradation, a changing climate, and extreme weather events. Rice production in Ecuador, mainly concentrated in lowland tropical plains, declined in recent years. In this paper, we aim to calibrate and validate Kobayashi’s ‘Very Simple Model’ (VSM) and, using downscaled corrected climate data, to quantify the potential impact of climate change on rice yields for Ecuador’s two main rice-growing provinces. The negative impact is expected to be highest (up to −67%; 2946 tons) under the Representative Concentration Pathway (RCP) 8.5, with a lower impact under RCP 2.6 (−36%; 1650 tons) yield reduction in the Guayas province. A positive impact on yield is predicted for Los Ríos Province (up to 9%; 161 tons) under RCP 8.5. These different impacts indicate the utility of fine-scale analyses using simple models to make predictions that are relevant to regional production scenarios. Our prediction of possible changes in rice productivity can help policymakers define a variety of requirements to meet the demands of a changing climate.