Ver publicación 

Mostrar el registro sencillo de la publicación

Rational design, synthesis and evaluation of γ-CD-containing cross-linked polyvinyl alcohol hydrogel as a prednisone delivery platform

dc.contributor.authorMarican, Adolfo
dc.contributor.authorAvila-Salas, Fabian
dc.contributor.authorValdés, Oscar
dc.contributor.authorWehinger, Sergio
dc.contributor.authorVillaseñor, Jorge
dc.contributor.authorFuentealba, Natalia
dc.contributor.authorArenas-Salinas, Mauricio
dc.contributor.authorArgandoña, Yerko
dc.contributor.authorCarrasco-Sánchez, Verónica
dc.contributor.authorDurán-Lara, Esteban F.
dc.date.accessioned2022-12-29T17:43:39Z
dc.date.available2022-12-29T17:43:39Z
dc.date.issued2018
dc.identifier.urihttp://repositorio.ucm.cl/handle/ucm/4284
dc.description.abstractThis study describes the in-silico rational design, synthesis and evaluation of cross-linked polyvinyl alcohol hydrogels containing γ-cyclodextrin (γ-CDHSAs) as platforms for the sustained release of prednisone (PDN). Through in-silico studies using semi-empirical quantum mechanical calculations, the effectiveness of 20 dicarboxylic acids to generate a specific cross-linked hydrogel capable of supporting different amounts of γ-cyclodextrin (γ-CD) was evaluated. According to the interaction energies calculated with the in-silico studies, the hydrogel made from PVA cross-linked with succinic acids (SA) was shown to be the best candidate for containing γ-CD. Later, molecular dynamics simulation studies were performed in order to evaluate the intermolecular interactions between PDN and three cross-linked hydrogel formulations with different proportions of γ-CD (2.44%, 4.76% and 9.1%). These three cross-linked hydrogels were synthesized and characterized. The loading and the subsequent release of PDN from the hydrogels were investigated. The in-silico and experimental results showed that the interaction between PDN and γ-CDHSA was mainly produced with the γ-CDs linked to the hydrogels. Thus, the unique structures and properties of γ-CDHSA demonstrated an interesting multiphasic profile that could be utilized as a promising drug carrier for controlled, sustained and localized release of PDN.es_CL
dc.language.isoenes_CL
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
dc.sourcePharmaceutics, 10(1), 30es_CL
dc.subjectDrug deliveryes_CL
dc.subjectCrosslinkinges_CL
dc.subjectPrednisonees_CL
dc.subjectCyclodextrinses_CL
dc.subjectSwellinges_CL
dc.subjectAccumulative releasees_CL
dc.subjectThermogravimetric analysises_CL
dc.titleRational design, synthesis and evaluation of γ-CD-containing cross-linked polyvinyl alcohol hydrogel as a prednisone delivery platformes_CL
dc.typeArticlees_CL
dc.ucm.indexacionScopuses_CL
dc.ucm.indexacionIsies_CL
dc.ucm.doidoi.org/10.3390/pharmaceutics10010030es_CL


Ficheros en la publicación

Vista Previa No Disponible
Nombre:
license_rdf
Tamaño:
811bytes
Formato:
application/rdf+xml
Ver/
Thumbnail
Nombre:
marican_a_rational.pdf
Tamaño:
10.38Mb
Formato:
PDF
Ver/

Esta publicación aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo de la publicación

Atribución-NoComercial-SinDerivadas 3.0 Chile
Excepto si se señala otra cosa, la licencia de la publicación se describe como Atribución-NoComercial-SinDerivadas 3.0 Chile