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Hydroxytyrosol supplementation ameliorates the metabolic disturbances in white adipose tissue from mice fed a high-fat diet through recovery of transcription factors Nrf2, SREBP-1c, PPAR-γ and NF-κB

dc.contributor.authorIllesca, Paola
dc.contributor.authorValenzuela, Rodrigo
dc.contributor.authorEspinosa, Alejandra
dc.contributor.authorEcheverría, Francisca
dc.contributor.authorSoto-Alarcon, Sandra
dc.contributor.authorOrtiz, Macarena
dc.contributor.authorVidela, Luis A.
dc.date.accessioned2023-01-16T19:20:11Z
dc.date.available2023-01-16T19:20:11Z
dc.date.issued2019
dc.identifier.urihttp://repositorio.ucm.cl/handle/ucm/4368
dc.description.abstractBackground: White adipose tissue (WAT) have a relevant metabolic and inflammatory function, in overweight or obesity conditions. In this regard, the WAT under over feeding nutrition present a significant increment in oxidative stress, pro-inflammatory status and depletion of n-3 long chain polyunsaturated fatty acid. Hydroxytyrosol (HT) is a polyphenol with important cytoprotective effects, and this molecule can modulate the gene expression, transcription factors and enzymatic activity. Objective: Therefore, the purpose of this study was evaluate the anti-inflammatory, anti-oxidant and anti-lipogenic effects of HT supplementation mice and the molecular adaptations involved, on dysfunctional WAT from high-fat diet (HFD)-fed mice. Methods and results: Male C57BL/6 J mice received (i) control diet (10% fat); (ii) control diet + HT (daily doses of 5 mg kg body weight), (iii) HFD (60% fat); or (iv) HFD + HT for 12 weeks. HFD-fed mice exhibited: (i) WAT hypertrophy; (ii) oxidative stress and depletion of antioxidant defenses, (iii) increased lipogenesis and pro-inflammatory status, (iv) depletion of n-3 LCPUFA and (v) up-regulation of NF-κB and SREBP 1c with down-regulation Nrf2, and PPAR-γ. HT supplementation attenuated the metabolic impairment produced by HFD in WAT, attenuating increment of NF-κB and SREBP 1c, and increasing the activity of Nrf2 and PPAR-γ. Conclusion: Supplementation with HT improve the WAT dysfunction induced by HDF in mice through the modulation of transcription factors NF-κB, Nrf2, SREBP-1c and PPAR-γ as well as their target genes, involved in inflammation, antioxidant defenses and lipogenesis.es_CL
dc.language.isoenes_CL
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
dc.sourceBiomedicine & Pharmacotherapy, 109, 2472-2481es_CL
dc.subjectWhite adipose tissuees_CL
dc.subjectHydroxytyrosoles_CL
dc.subjectOxidative stresses_CL
dc.subjectNrf2es_CL
dc.subjectPPAR-γes_CL
dc.subjectNF-κBes_CL
dc.titleHydroxytyrosol supplementation ameliorates the metabolic disturbances in white adipose tissue from mice fed a high-fat diet through recovery of transcription factors Nrf2, SREBP-1c, PPAR-γ and NF-κBes_CL
dc.typeArticlees_CL
dc.ucm.facultadFacultad de Ciencias de la Saludes_CL
dc.ucm.indexacionScopuses_CL
dc.ucm.indexacionIsies_CL
dc.ucm.uriwww.sciencedirect.com/science/article/pii/S0753332218365612?via%3Dihubes_CL
dc.ucm.doidoi.org/10.1016/j.biopha.2018.11.120es_CL


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Atribución-NoComercial-SinDerivadas 3.0 Chile
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