Genotoxicity and reproductive risk in workers exposed to pesticides in rural areas of Curicó, Chile: a pilot study

Landeros, Natalia; Duk, Soledad; Márquez, Carolina; Inzunza, Bárbara; Acuña-Rodríguez, Ian S.; Zúñiga-Venegas, Liliana A.

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dc.contributor.author	Landeros, Natalia
dc.contributor.author	Duk, Soledad
dc.contributor.author	Márquez, Carolina
dc.contributor.author	Inzunza, Bárbara
dc.contributor.author	Acuña-Rodríguez, Ian S.
dc.contributor.author	Zúñiga-Venegas, Liliana A.
dc.date.accessioned	2023-01-20T12:22:01Z
dc.date.available	2023-01-20T12:22:01Z
dc.date.issued	2022
dc.identifier.uri	http://repositorio.ucm.cl/handle/ucm/4399
dc.description.abstract	Significant risks to human health have been associated with chronic exposure to low doses of pesticides, a situation which may be frequent among agricultural workers. In this context, and regarding the agricultural-based economy of central Chile, we aimed to explore the genotoxic damage in agricultural workers and reproductive risk among women in rural and urban areas of Curicó, a traditional agricultural district in Chile. Hence, we sampled a group of rural agricultural workers associated with pesticide management (n = 30) and an urban unexposed group (n = 30). Our results showed that the agricultural workers had higher micronuclei frequencies (MN: β = 13.27; 95% CI low = 11.08, CI high = 15.47) and women had a 40-fold higher risk of reproductive problems (OR = 40.32; 95% CI low = 2.60, CI high = 624.31) than the unexposed group. The factor analysis of mixed data (FAMD) showed that neither the sex nor smoking habits appear to define the ordination of the data. Nevertheless, the exposure level did segregate them in the multidimensional space (explained variance: 35.38% dim-1; 18.63% dim-2). This pilot study highlights the higher risks of biological conditions negatively associated with the health of agricultural workers.	es_CL
dc.language.iso	en	es_CL
dc.rights	Atribución-NoComercial-SinDerivadas 3.0 Chile	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/cl/	*
dc.source	International Journal of Environmental Research and Public Health, 19(24), 16608	es_CL
dc.subject	Genotoxicity	es_CL
dc.subject	Reproductive risk	es_CL
dc.subject	Agricultural workers	es_CL
dc.subject	Pesticide exposure	es_CL
dc.subject	Chile	es_CL
dc.title	Genotoxicity and reproductive risk in workers exposed to pesticides in rural areas of Curicó, Chile: a pilot study	es_CL
dc.type	Article	es_CL
dc.ucm.facultad	Facultad de Medicina	es_CL
dc.ucm.indexacion	Scopus	es_CL
dc.ucm.indexacion	Isi	es_CL
dc.ucm.uri	mdpi.com/1660-4601/19/24/16608	es_CL
dc.ucm.doi	doi.org/10.3390/ijerph192416608	es_CL