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An opportunity for prevention: associations between the life's essential 8 score and cardiovascular incidence using prospective data from uk biobank
| dc.contributor.author | Petermann-Rocha, Fanny | |
| dc.contributor.author | Deo, Salil | |
| dc.contributor.author | Celis-Morales, Carlos | |
| dc.contributor.author | Ho, Frederick | |
| dc.contributor.author | Bahuguna, Pankaj | |
| dc.contributor.author | McAllister, David | |
| dc.contributor.author | Sattar, Naveed | |
| dc.contributor.author | Pell, J.P. | |
| dc.date.accessioned | 2023-01-23T18:08:49Z | |
| dc.date.available | 2023-01-23T18:08:49Z | |
| dc.date.issued | 2023 | |
| dc.identifier.uri | http://repositorio.ucm.cl/handle/ucm/4442 | |
| dc.description.abstract | To investigate the association between the Life's Essential 8 (LE8) score and the incidence of four cardiovascular outcomes (ischemic heart disease, myocardial infarction, stroke, and heart failure [HF]) – separately and as a composite outcome of major adverse cardiovascular events (MACE) – in UK Biobank. 250,825 participants were included in this prospective study. Smoking, non-HDL cholesterol, blood pressure, body mass index, HbA1c, physical activity, diet, and sleep were used to create a modified version of the LE8 score. Associations between the score (both as a continuous score and as quartiles) and outcomes were investigated using adjusted Cox proportional hazard models. The potential impact fractions of two scenarios were also calculated. Over a median follow-up of 10.4 years, there were 25,068 MACE. Compared to individuals in the highest quartile of the score (healthiest), those in the lowest quartile (least healthy) had 2.07 (95% CI: 1.99; 2.16) higher risk for MACE. The highest relative risk gradient of the individual outcomes was observed for HF (HRlowest quartile: 2.67 [95% CI: 2.42; 2.94]). The magnitude of association was stronger in participants below 50 years, women, and ethnic minorities. A targeted intervention that increased, by 10-points, the score among individuals in the lowest quartile could have prevented 9.2% of MACE. Individuals with a lower LE8 score experienced more MACE, driven especially by incident HF. Our scenarios suggested that relevant interventions targeted towards those in the lowest quartile may have a greater impact than interventions producing small equal changes across all quartiles. | es_CL |
| dc.language.iso | en | es_CL |
| dc.rights | Atribución-NoComercial-SinDerivadas 3.0 Chile | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | * |
| dc.source | Current Problems in Cardiology, 48(4), 101540 | es_CL |
| dc.title | An opportunity for prevention: associations between the life's essential 8 score and cardiovascular incidence using prospective data from uk biobank | es_CL |
| dc.type | Article | es_CL |
| dc.ucm.indexacion | Scopus | es_CL |
| dc.ucm.indexacion | Isi | es_CL |
| dc.ucm.uri | sciencedirect.com/science/article/abs/pii/S0146280622004376?via%3Dihub | es_CL |
| dc.ucm.doi | doi.org/10.1016/j.cpcardiol.2022.101540 | es_CL |
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Excepto si se señala otra cosa, la licencia de la publicación se describe como Atribución-NoComercial-SinDerivadas 3.0 Chile