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Identifying the biomarker profile of pre-frail and frail people: a cross-sectional analysis from UK biobank

dc.contributor.authorChu, Wenying
dc.contributor.authorLynskey, Nathan
dc.contributor.authorIain-Ross, James
dc.contributor.authorPell, J.P.
dc.contributor.authorSattar, Naveed
dc.contributor.authorHo, Frederick
dc.contributor.authorWelsh, Paul
dc.contributor.authorCelis-Morales, Carlos
dc.contributor.authorPetermann-Rocha, Fanny
dc.date.accessioned2023-03-21T20:08:41Z
dc.date.available2023-03-21T20:08:41Z
dc.date.issued2023
dc.identifier.urihttp://repositorio.ucm.cl/handle/ucm/4533
dc.description.abstractObjective: This study aimed to compare the biomarker profile of pre-frail and frail adults in the UK Biobank cohort by sex. Methods: In total, 202,537 participants (67.8% women, aged 37 to 73 years) were included in this cross-sectional analysis. Further, 31 biomarkers were investigated in this study. Frailty was defined using a modified version of the Frailty Phenotype. Multiple linear regression analyses were performed to explore the biomarker profile of pre-frail and frail individuals categorized by sex. Results: Lower concentrations of apoA1, total, LDL, and HDL cholesterol, albumin, eGFRcys, vitamin D, total bilirubin, apoB, and testosterone (differences ranged from −0.30 to −0.02 per 1-SD change), as well as higher concentrations of triglycerides, GGT, cystatin C, CRP, ALP, and phosphate (differences ranged from 0.01 to 0.53 per 1-SD change), were identified both in pre-frail and frail men and women. However, some of the associations differed by sex. For instance, higher rheumatoid factor and urate concentrations were identified in pre-frail and frail women, while lower calcium, total protein, and IGF-1 concentrations were identified in pre-frail women and frail women and men. When the analyses were further adjusted for CRP, similar results were found. Conclusions: Several biomarkers were linked to pre-frailty and frailty. Nonetheless, some of the associations differed by sex. Our findings contribute to a broader understanding of the pathophysiology of frailty as currently defined.es_CL
dc.language.isoenes_CL
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
dc.sourceInternational Journal of Environmental Research and Public Health, 20(3), 2421es_CL
dc.subjectFrailtyes_CL
dc.subjectAginges_CL
dc.subjectBiomarkerses_CL
dc.subjectUK Biobankes_CL
dc.titleIdentifying the biomarker profile of pre-frail and frail people: a cross-sectional analysis from UK biobankes_CL
dc.typeArticlees_CL
dc.ucm.indexacionScopuses_CL
dc.ucm.indexacionIsies_CL
dc.ucm.urimdpi.com/1660-4601/20/3/2421es_CL
dc.ucm.doidoi.org/10.3390/ijerph20032421es_CL


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