Heart rate from progressive volitional cycling test is associated with endothelial dysfunction outcomes in hypertensive chilean adults

Alvarez, Cristian; Tuesta, Marcelo; Reyes, Álvaro; Guede Rojas, Francisco; Peñailillo, Luis; Cigarroa, Igor; Vásquez-Gómez, Jaime A.; Cano-Montoya, Johnattan; Durán-Marín, Cristóbal; Rojas-Paz, Oscar; Márquez, Héctor; Izquierdo, Mikel; Delgado-Floody, Pedro

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dc.contributor.author	Alvarez, Cristian
dc.contributor.author	Tuesta, Marcelo
dc.contributor.author	Reyes, Álvaro
dc.contributor.author	Guede Rojas, Francisco
dc.contributor.author	Peñailillo, Luis
dc.contributor.author	Cigarroa, Igor
dc.contributor.author	Vásquez-Gómez, Jaime A.
dc.contributor.author	Cano-Montoya, Johnattan
dc.contributor.author	Durán-Marín, Cristóbal
dc.contributor.author	Rojas-Paz, Oscar
dc.contributor.author	Márquez, Héctor
dc.contributor.author	Izquierdo, Mikel
dc.contributor.author	Delgado-Floody, Pedro
dc.date.accessioned	2023-03-29T12:37:19Z
dc.date.available	2023-03-29T12:37:19Z
dc.date.issued	2023
dc.identifier.uri	http://repositorio.ucm.cl/handle/ucm/4598
dc.description.abstract	Background: A progressive volitional cycling test is useful in determining exercise prescription in populations with cardiovascular and metabolic diseases. However, little is known about the association between heart rate during this test and endothelial dysfunction (EDys) parameters in hypertensive (HTN) patients. Objective: To investigate the association between EDys markers (flowmediated dilation [FMD], pulse wave velocity of the brachial artery [PWVba], and carotid-intima media thickness [cIMT]) and heart rate during a cycling test in HTN adults. A secondary aim was to characterize cardiovascular, anthropometric, and body composition outcomes in this population. Methods: This was a descriptive clinical study in which adults (men and women) were assigned to one of three groups: HTN, elevated blood pressure (Ele), or a normotensive control group (CG), and completed a progressive cycling test. The primary outcomes were FMD, PWVba, cIMT, and heart rate (HR) at 25–50 watts (HR25–50), 50–100 watts (HR50–100), and 75–150 watts (HR75–150) of the Astrand test. Secondary outcomes included body mass index (BMI), waist circumference, body fat percentage (BF%), skeletal muscle mass (SMM), resting metabolic rate (RMR), and estimated body age, as measured by a bio-impedance digital scale. Results: Analyses of the associations between FMD, PWV, and HR25–50, HR50–100, and HR75–150 watts revealed no significant association in the HTN, Ele, and CG groups. However, a significant association was found between cIMT and HR75–150 watts in the HTN group (R2 47.1, β −0.650, p = 0.038). There was also a significant trend (p = 0.047) towards increasing PWVba in the CG, Ele, and HTN groups. Conclusion: Heart rate during a progressive cycling test is associated with the EDys parameters cIMT in HTN patients, with particularly strong predictive capacity for vascular parameters in the second and third stages of the Astrand exercise test compared to normotensive control.	es_CL
dc.language.iso	en	es_CL
dc.rights	Atribución-NoComercial-SinDerivadas 3.0 Chile	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/cl/	*
dc.source	International Journal of Environmental Research and Public Health, 20(5), 4236	es_CL
dc.subject	Flow-mediated dilation	es_CL
dc.subject	Pulse wave velocity	es_CL
dc.subject	Carotid-intima media thickness	es_CL
dc.subject	Endothelial dysfunction	es_CL
dc.subject	Arterial hypertension	es_CL
dc.subject	Exercise test	es_CL
dc.subject	Vasculature	es_CL
dc.title	Heart rate from progressive volitional cycling test is associated with endothelial dysfunction outcomes in hypertensive chilean adults	es_CL
dc.type	Article	es_CL
dc.ucm.indexacion	Scopus	es_CL
dc.ucm.indexacion	Isi	es_CL
dc.ucm.uri	mdpi.com/1660-4601/20/5/4236	es_CL
dc.ucm.doi	doi.org/10.3390/ijerph20054236	es_CL