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Transcranial cortico-cortical paired associative stimulation (ccPAS) over ventral premotor-motor pathways enhances action performance and corticomotor excitability in young adults more than in elderly adults
| dc.contributor.author | Turrini, Sonia | |
| dc.contributor.author | Bevacqua, Naomi | |
| dc.contributor.author | Cataneo, Antonio | |
| dc.contributor.author | Chiappini, Emilio | |
| dc.contributor.author | Fiori, Francesca | |
| dc.contributor.author | Candidi, Matteo | |
| dc.contributor.author | Avenanti, Alessio | |
| dc.date.accessioned | 2023-04-04T20:27:56Z | |
| dc.date.available | 2023-04-04T20:27:56Z | |
| dc.date.issued | 2023 | |
| dc.identifier.uri | http://repositorio.ucm.cl/handle/ucm/4606 | |
| dc.description.abstract | Transcranial magnetic stimulation (TMS) methods such as cortico-cortical paired associative stimulation (ccPAS) can increase the strength of functional connectivity between ventral premotor cortex (PMv) and primary motor cortex (M1) via spike timing-dependent plasticity (STDP), leading to enhanced motor functions in young adults. However, whether this STDP-inducing protocol is effective in the aging brain remains unclear. In two groups of young and elderly healthy adults, we evaluated manual dexterity with the 9-hole peg task before and after ccPAS of the left PMvM1 circuit. We observed that ccPAS enhanced dexterity in young adults, and this effect was anticipated by a progressive increase in motor-evoked potentials (MEPs) during ccPAS administration. No similar effects were observed in elderly individuals or in a control task. Across age groups, we observed that the magnitude of MEP changes predicted larger behavioral improvements. These findings demonstrate that left PMv-to-M1 ccPAS induces functionally specific improvements in young adults’ manual dexterity and an increase in corticomotor excitability, but altered plasticity prevents the effectiveness of ccPAS in the elderly. | es_CL |
| dc.language.iso | en | es_CL |
| dc.rights | Atribución-NoComercial-SinDerivadas 3.0 Chile | * |
| dc.rights | Atribución-NoComercial-SinDerivadas 3.0 Chile | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | * |
| dc.source | Frontiers in Aging Neuroscience, 15, 1119508 | es_CL |
| dc.subject | TMS | es_CL |
| dc.subject | ccPAS | es_CL |
| dc.subject | Hebbian plasticity | es_CL |
| dc.subject | Manual dexterity | es_CL |
| dc.subject | Aging | es_CL |
| dc.subject | Motor system | es_CL |
| dc.title | Transcranial cortico-cortical paired associative stimulation (ccPAS) over ventral premotor-motor pathways enhances action performance and corticomotor excitability in young adults more than in elderly adults | es_CL |
| dc.type | Article | es_CL |
| dc.ucm.indexacion | Scopus | es_CL |
| dc.ucm.indexacion | Isi | es_CL |
| dc.ucm.uri | frontiersin.org/articles/10.3389/fnagi.2023.1119508/full | es_CL |
| dc.ucm.doi | doi.org/10.3389/fnagi.2023.1119508 | es_CL |
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