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Modulation of response times in early-stage Parkinson’s disease during emotional processing of embodied and non-embodied stimuli

dc.contributor.authorBotta, Alessandro
dc.contributor.authorPelosin, Elisa
dc.contributor.authorLagravinese, Giovanna
dc.contributor.authorMarchese, Roberta
dc.contributor.authorDi Biasio, Francesca
dc.contributor.authorBonassi, Gaia
dc.contributor.authorTerranova, Sara
dc.contributor.authorRavizzotti, Elisa
dc.contributor.authorPutzolu, Martina
dc.contributor.authorMezzarobba, Susanna
dc.contributor.authorCosentino, Carola
dc.contributor.authorAvenanti, Alessio
dc.contributor.authorAvanzino, Laura
dc.date.accessioned2024-07-09T14:15:18Z
dc.date.available2024-07-09T14:15:18Z
dc.date.issued2024
dc.identifier.urihttp://repositorio.ucm.cl/handle/ucm/5483
dc.description.abstractValence (positive and negative) and content (embodied vs non-embodied) characteristics of visual stimuli have been shown to influence motor readiness, as tested with response time paradigms. Both embodiment and emotional processing are affected in Parkinson’s disease (PD) due to basal ganglia dysfunction. Here we aimed to investigate, using a two-choice response time paradigm, motor readiness when processing embodied (emotional body language [EBL] and emotional facial expressions [FACS]) vs non-embodied (emotional scenes [IAPS]) stimuli with neutral, happy, and fearful content. We enrolled twenty-five patients with early-stage PD and twenty-five age matched healthy participants. Motor response during emotional processing was assessed by measuring response times (RTs) in a home-based, forced two-choice discrimination task where participants were asked to discriminate the emotional stimulus from the neutral one. Rating of valence and arousal was also performed. A clinical and neuropsychological evaluation was performed on PD patients. Results showed that RTs for PD patients were longer for all conditions compared to HC and that RTs were generally longer in both groups for EBL compared to FACS and IAPS, with the sole exception retrieved for PD, where in discriminating fearful stimuli, RTs for EBL were longer compared to FACS but not to IAPS. Furthermore, in PD only, when discriminating fearful respect to neutral stimuli, RTs were shorter when discriminating FACS compared to IAPS. This study shows that PD patients were faster in discriminating fearful embodied stimuli, allowing us to speculate on mechanisms involving an alternative, compensatory, emotional motor pathway for PD patients undergoing fear processing.es_CL
dc.language.isoenes_CL
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
dc.sourceScientific Reports, 14, 13031es_CL
dc.subjectParkinson’s diseasees_CL
dc.subjectEmbodimentes_CL
dc.subjectEmotiones_CL
dc.subjectResponse timees_CL
dc.titleModulation of response times in early-stage Parkinson’s disease during emotional processing of embodied and non-embodied stimulies_CL
dc.typeArticlees_CL
dc.ucm.indexacionScopuses_CL
dc.ucm.indexacionIsies_CL
dc.ucm.urinature.com/articles/s41598-024-63701-9es_CL
dc.ucm.doidoi.org/10.1038/s41598-024-63701-9es_CL


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Atribución-NoComercial-SinDerivadas 3.0 Chile
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