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Dose and time–response effect of photobiomodulation therapy on glycemic control in type 2 diabetic patients combined or not with hypoglycemic medicine: a randomized, crossover, double-blind, sham-controlled trial
| dc.contributor.author | Cobra Branco Scontri, Clara Maria | |
| dc.contributor.author | de Castro Magalhães, Flávio | |
| dc.contributor.author | Moraes Damiani, Ana Paula | |
| dc.contributor.author | Hamblin, Michael R. | |
| dc.contributor.author | Zamunér, Antonio Roberto | |
| dc.contributor.author | Ferraresi, Cleber | |
| dc.date.accessioned | 2024-08-07T14:41:28Z | |
| dc.date.available | 2024-08-07T14:41:28Z | |
| dc.date.issued | 2023 | |
| dc.identifier.uri | http://repositorio.ucm.cl/handle/ucm/5574 | |
| dc.description.abstract | Photobiomodulation therapy (PBMt) combined or not with oral hypoglycemic medication has not been investigated in type 2 diabetes (T2DM) patients. All 10 T2DM patients were assessed randomly at 6 different occasions (3 with and 3 without regular oral hypoglycemic medication). Capillary glycemia was assessed after overnight fast (pre-prandial), 1 h postprandially (standardized meal, 338 kcal), and 30 min, 3 h, 6 h, 12 h post-PBMt (830 nm; 25 arrays of LEDs, 80 mW/array). Three doses (0 J—sham, 100 J, 240 J per site) were applied bilaterally on quadriceps femoris muscles, hamstrings, triceps surae, ventral upper arm and forearm; and randomly combined or not with oral hypoglicemic medication, totaling six different therapies applied for all 10 TDM2 patients (PBMt sham, PBMt 100 J, PBMt 240 J, PBMt sham + medication, PBMt 100 J + medication, PBMt 240 J + medication). Cardiac autonomic control was assessed by heart rate variability (HRV) indices. Without medication, there was reduction in glycemia after all PBMt doses, with 100 J as the best dose that persisted until 12 h and presented lower area under the curve (AUC). With medication, glycemia decreased similarly among doses. No differences between 100 J and sham + medication, but AUC was significantly lower after 100 J, suggesting better glycemic control. Low frequency component of HRV increased after sham + medication and 100 J, suggesting higher sympathetic activation. PBMt showed time– and dose–response effect to reduce glycemia in T2DM patients. Effects on HRV were consistent with glycemic control. | es_CL |
| dc.language.iso | en | es_CL |
| dc.rights | Atribución-NoComercial-SinDerivadas 3.0 Chile | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | * |
| dc.source | Journal of Biophotonics, 16(10), e202300083 | es_CL |
| dc.subject | Dose–response | es_CL |
| dc.subject | Glycemic control | es_CL |
| dc.subject | Heart rate variability | es_CL |
| dc.subject | Hypoglycemic drugs | es_CL |
| dc.subject | Insulin resistance | es_CL |
| dc.subject | Photobiomodulation therapy | es_CL |
| dc.title | Dose and time–response effect of photobiomodulation therapy on glycemic control in type 2 diabetic patients combined or not with hypoglycemic medicine: a randomized, crossover, double-blind, sham-controlled trial | es_CL |
| dc.type | Article | es_CL |
| dc.ucm.facultad | Facultad de Ciencias de la Salud | es_CL |
| dc.ucm.indexacion | Scopus | es_CL |
| dc.ucm.indexacion | Isi | es_CL |
| dc.ucm.uri | onlinelibrary.wiley.com/doi/10.1002/jbio.202300083 | es_CL |
| dc.ucm.doi | doi.org/10.1002/jbio.202300083 | es_CL |
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Excepto si se señala otra cosa, la licencia de la publicación se describe como Atribución-NoComercial-SinDerivadas 3.0 Chile