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The endocannabinoid peptide RVD-hemopressin Is a TRPV1 channel blocker
| dc.contributor.author | Suárez-Suárez, Constanza | |
| dc.contributor.author | González-Pérez, Sebastián | |
| dc.contributor.author | Márquez-Miranda, Valeria | |
| dc.contributor.author | Araya‑Duran, Ingrid | |
| dc.contributor.author | Vidal-Beltrán, Isabel | |
| dc.contributor.author | Vergara, Sebastián | |
| dc.contributor.author | Carvacho, Ingrid | |
| dc.contributor.author | Hinostroza, Fernando | |
| dc.date.accessioned | 2024-11-15T14:22:08Z | |
| dc.date.available | 2024-11-15T14:22:08Z | |
| dc.date.issued | 2024 | |
| dc.identifier.uri | http://repositorio.ucm.cl/handle/ucm/5746 | |
| dc.description.abstract | Neurotransmission is critical for brain function, allowing neurons to communicate through neurotransmitters and neuropeptides. RVD-hemopressin (RVD-Hp), a novel peptide identified in noradrenergic neurons, modulates cannabinoid receptors CB1 and CB2. Unlike hemopressin (Hp), which induces anxiogenic behaviors via transient receptor potential vanilloid 1 (TRPV1) activation, RVD-Hp counteracts these effects, suggesting that it may block TRPV1. This study investigates RVD-Hp’s role as a TRPV1 channel blocker using HEK293 cells expressing TRPV1-GFP. Calcium imaging and patch-clamp recordings demonstrated that RVD-Hp reduces TRPV1-mediated calcium influx and TRPV1 ion currents. Molecular docking and dynamics simulations indicated that RVD-Hp interacts with TRPV1’s selectivity filter, forming stable hydrogen bonds and van der Waals contacts, thus preventing ion permeation. These findings highlight RVD-Hp’s potential as a therapeutic agent for conditions involving TRPV1 activation, such as pain and anxiety. | es_CL |
| dc.language.iso | en | es_CL |
| dc.rights | Atribución-NoComercial-SinDerivadas 3.0 Chile | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | * |
| dc.source | Biomolecules, 14(9), 1134 | es_CL |
| dc.subject | RVD-hemopressin | es_CL |
| dc.subject | TRPV1 channel | es_CL |
| dc.subject | Calcium imaging | es_CL |
| dc.subject | Patch-clamp electrophysiology | es_CL |
| dc.subject | Molecular dynamics simulations | es_CL |
| dc.title | The endocannabinoid peptide RVD-hemopressin Is a TRPV1 channel blocker | es_CL |
| dc.type | Article | es_CL |
| dc.ucm.facultad | Facultad de Medicina | es_CL |
| dc.ucm.indexacion | Scopus | es_CL |
| dc.ucm.indexacion | Isi | es_CL |
| dc.ucm.uri | mdpi.com/2218-273X/14/9/1134 | es_CL |
| dc.ucm.doi | doi.org/10.3390/biom14091134 | es_CL |
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Excepto si se señala otra cosa, la licencia de la publicación se describe como Atribución-NoComercial-SinDerivadas 3.0 Chile