Prenatal valproate treatment produces autistic-like behavior and increases metabotropic glutamate receptor 1A-immunoreactivity in the hippocampus of juvenile rats

Aliaga-Rojas, Esteban; Peralta, Francisco; Fuentealba, Constanza

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dc.contributor.author	Aliaga-Rojas, Esteban
dc.contributor.author	Peralta, Francisco
dc.contributor.author	Fuentealba, Constanza
dc.date.accessioned	2017-10-17T17:09:35Z
dc.date.available	2017-10-17T17:09:35Z
dc.date.issued	2016
dc.identifier.uri	http://repositorio.ucm.cl/handle/ucm/607
dc.description.abstract	Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder characterized by deficits in social communication and social interaction, and repetitive and stereotypical patterns of behavior. Previously, a common physiopathological pathway, involving the control of synaptic protein synthesis, was proposed as a convergence point in ASD. In particular, a role for local mRNA translation activated by class I metabotropic glutamate receptor type 5 (mGluR5) was suggested in genetic syndromes with autistic signs and in the prenatal exposition to the valproate model of autism. However, the role of the other members of class I metabotropic glutamate receptors, including mGluR1, has been poorly studied. The present study analyzed the immunoreactivity for mGluR1a in the hippocampus of rats prenatally treated with valproate. Pregnant dams (embryonic day 12.5) were injected with valproate (450 mg/kg) and subsequently, the behavior and mGluR1a were evaluated at postnatal day 30. Experimental rats exhibited social deficit, repetitive conduct and anxious behaviors compared with that of the control animals. Additionally, the present study observed an increased level of mGluR1a-immunoreactivity in the hilus of dentate gyrus and in the CA1 alveus region of the hippocampus. These results suggested an over‑functioning of mGluR1a signaling in the hippocampus, induced in the valproate model of autism, which may serve a role in cognitive and behavioral signs of ASD.	es_CL
dc.language.iso	en	es_CL
dc.rights	Atribución-NoComercial-SinDerivadas 3.0 Chile	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/cl/	*
dc.source	Molecular Medicine Reports, 14, 2807-2814	es_CL
dc.subject	Metabotropic glutamate receptor 1A	es_CL
dc.subject	Autism	es_CL
dc.subject	Valproate	es_CL
dc.subject	Prenatal	es_CL
dc.subject	Hippocampus	es_CL
dc.subject	Alveus	es_CL
dc.subject	Hilus	es_CL
dc.title	Prenatal valproate treatment produces autistic-like behavior and increases metabotropic glutamate receptor 1A-immunoreactivity in the hippocampus of juvenile rats	es_CL
dc.type	Article	es_CL
dc.ucm.facultad	Facultad de Ciencias de la Salud	es_CL
dc.ucm.indexacion	Scopus	es_CL
dc.ucm.indexacion	Isi	es_CL
dc.ucm.doi	doi.org/10.3892/mmr.2016.5529	es_CL