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Relationship between plasma leptin levels and airflow limitation in the small and medium airways in young adults
| dc.contributor.author | Muñoz-Cofré, Rodrigo | |
| dc.contributor.author | Rojas-Mancilla, Edgardo | |
| dc.contributor.author | Lizana, Pablo A. | |
| dc.contributor.author | Escobar-Cabello, Máximo | |
| dc.contributor.author | García-Herrera, Claudio | |
| dc.contributor.author | Conei, Daniel | |
| dc.contributor.author | Valenzuela-Aedo, Fernando | |
| dc.contributor.author | Soto-Rodríguez, Francisco Javier | |
| dc.contributor.author | Del Sol, Mariano | |
| dc.date.accessioned | 2025-06-05T15:31:22Z | |
| dc.date.available | 2025-06-05T15:31:22Z | |
| dc.date.issued | 2025 | |
| dc.identifier.uri | http://repositorio.ucm.cl/handle/ucm/6100 | |
| dc.description.abstract | Background/Objectives: To determine the relationship between plasma leptin levels and airflow limitation (AFL) in the small and medium airways of young adults according to their body composition (BC). Methods: To determine AFL, the following measurements were taken: forced expiratory volume in the first second (FEV1), forced expiratory flow between 25–75% (FEF25–75%), airway resistance (Raw), and specific airway resistance (sRaw). The measured BC variables were body mass index (BMI), body fat percentage (%BF), trunk fat percentage (TF%), and fat-free mass (FFM). Plasma leptin was measured using the ELISA technique. Results: In total, 83 participants (40 male and 43 female) aged 21.55 ± 2.08 years were evaluated. Leptin was significantly higher in women than men (p < 0.01). When relating leptin to lung function variables, FEV1 and FEF25–75% showed a significant inverse relationship (p < 0.01), and Raw and sRaw showed a direct and significant relationship (p < 0.01). Female participants with a BF% and leptin higher than their p75 were observed to have a higher risk of increased sRaw (OR = 1.0; OR = 1.15, respectively), regardless of age, and participants with an FFM% higher than their p75 had a lower risk of increased sRaw (OR = 0.71), regardless of gender and age. Conclusions: There is an inverse relationship between FEV1, FEF25–75%, and a direct relationship between Raw and sRaw with leptin. For female participants with a higher BF%, higher FFM%, and leptin, the risk of developing Raw and sRaw was found to be modified. | es_CL |
| dc.language.iso | en | es_CL |
| dc.rights | Atribución-NoComercial-SinDerivadas 3.0 Chile | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | * |
| dc.source | Journal of Clinical Medicine, 14(5), 1624 | es_CL |
| dc.subject | Body composition | es_CL |
| dc.subject | Leptin | es_CL |
| dc.subject | Airflow | es_CL |
| dc.subject | Airway | es_CL |
| dc.subject | Young adult | es_CL |
| dc.title | Relationship between plasma leptin levels and airflow limitation in the small and medium airways in young adults | es_CL |
| dc.type | Article | es_CL |
| dc.ucm.facultad | Facultad de Ciencias de la Salud | es_CL |
| dc.ucm.indexacion | Scopus | es_CL |
| dc.ucm.indexacion | Isi | es_CL |
| dc.ucm.uri | mdpi.com/2077-0383/14/5/1624 | es_CL |
| dc.ucm.doi | doi.org/10.3390/jcm14051624 | es_CL |
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Excepto si se señala otra cosa, la licencia de la publicación se describe como Atribución-NoComercial-SinDerivadas 3.0 Chile