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Chronic stress triggers expression of immediate early genes and differentially affects the expression of AMPA and NMDA subunits in dorsal and ventral hippocampus of rats
Aliaga-Rojas, Esteban; Pacheco, Aníbal; Aguayo, Felipe I.; Muñoz, Mauricio; García-Rojo, Gonzalo; Olave, Felipe A.; Parra-Fiedler, Nicolás; García-Pérez, Alexandra; Tejos-Bravo, Macarena; Rojas, Paulina S.; Parra, Claudio S.; Fiedler, Jenny L. (2017)Previous studies in rats have demonstrated that chronic restraint stress triggers anhedonia, depressive-like behaviors, anxiety and a reduction in dendritic spine density in hippocampal neurons. In this study, we compared ...
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Deletion of hippocampal Glucocorticoid receptors unveils sex-biased microRNA expression and neuronal morphology alterations in mice
Tejos-Bravo, Macarena; Oakley, Robert H.; Whirledge, Shannon D.; Corrales, Wladimir; Silva, Juan P.; García-Rojo, Gonzalo; Toledo, Jorge; Sanchez, Wendy; Román-Albasini, Luciano; Aliaga-Rojas, Esteban; Aguayo, Felipe; Olave, Felipe A.; Marcaja-Coutinho, Vinicius; Cidlowski, John A.; Fiedler, Jenny L. (2021)Sex differences in the brain have prompted many researchers to investigate the underlying molecular actors, such as the glucocorticoid receptor (GR). This nuclear receptor controls gene expression, including microRNAs ...
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Dual effect of serotonin on the dendritic growth of cultured hippocampal neurons: Involvement of 5-HT1A and 5-HT7 receptors
Aliaga-Rojas, Esteban; Rojas, P.S.; Aguayo, Felipe I.; Neira, D.; Muñoz, J.P.; Tejos-Bravo, Macarena; Parra, Claudio S.; Fiedler, Jenny L. (2017)Serotonin acts through its receptors (5-HTRs) to shape brain networks during development and modulates essential functions in mature brain. The 5-HT1AR is mainly located at soma of hippocampal neurons early during brain ...
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Hippocampal memory recovery after acute stress: A behavioral, morphological and molecular study
Aguayo, Felipe I.; Tejos-Bravo, Macarena; Díaz-Véliz, Gabriela; Pacheco, Aníbal; García-Rojo, Gonzalo; Corrales, Wladimir; Olave, Felipe A.; Aliaga-Rojas, Esteban; Ulloa, José L.; Avalos, Ana M.; Román-Albasini, Luciano; Rojas, Paulina S.; Fiedler, Jenny L. (2018)Several studies have shown that a single exposure to stress may improve or impair learning and memory processes, depending on the timing in which the stress event occurs with relation to the acquisition phase. However, to ...
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MicroRNA profiling and bioinformatics target analysis in dorsal hippocampus of chronically stressed rats: Relevance to depression pathophysiology
Muñoz-Llanos, Mauricio; García-Pérez, María A.; Xu, Xiaojiang; Tejos-Bravo, Macarena; Vidal, Elena A.; Moyano, Tomás C.; Gutiérrez, Rodrigo A.; Aguayo, Felipe I.; Pacheco, Aníbal; García-Rojo, Gonzalo; Aliaga-Rojas, Esteban; Rojas, Paulina S.; Cidlowski, John A.; Fiedler, Jenny L. (2018)Studies conducted in rodents subjected to chronic stress and some observations in humans after psychosocial stress, have allowed to establish a link between stress and the susceptibility to many complex diseases, including ...