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Mostrando publicaciones 1-14 de 14
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Cytotoxic effect of geranylphenol derivatives in the human breast cancer cell line MDA-MB-231 and gastric cancer cell line MKN74
Espinoza, Luis; Taborga, Lautaro; Araya, Paulina; Delgado-López, Fernando; Zamora-León, Pilar (2020)Background: Previous studies have demonstrated that geranyl metabolites, found mainly in marine organisms, exhibit interesting antimicrobial and antifungal activities. In addition, linear geranyl derivatives have been ...
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Extracellular matrix glycation and receptor for advanced glycation end-products activation: A missing piece in the puzzle of the association between diabetes and cancer
A growing body of epidemiologic evidence suggests that people with diabetes are at a significantly higher risk of many forms of cancer. However, the molecular mechanisms underlying this association are not fully understood. ...
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Gastric tumor microenvironment
A compelling body of evidence has demonstrated that gastric cancer has a very particular tumor microenvironment, a signature very suitable to promote tumor progression and metastasis. Recent investigations have provided ...
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Helicobacter pylori infection and lung cancer: New insights and future challenges
Helicobacter pylori (H. pylori) is the causative agent of chronic gastritis and peptic ulcer diseases and is an important risk factor for the development functional dyspepsia, peptic ulceration, gastric adenocarcinoma and ...
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HMGB1 decreases CCR-2 expression and migration of M2 macrophages under hypoxia
Araya, Paulina; Romero, Jacqueline; Delgado-López, Fernando; Gonzalez, Ileana; Añazco-Oyarzún, Carolina; Perez, Ramón; Rojas, Armando (2019)Objective: The hypoxic milieu at tumor microenvironment is able to drive the behavior of infiltrating tumor cells. Considering that hypoxia-mediated HMGB1 release is known to promote tumor growth, as well to enhance the ...
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HMGB1 enhances the protumoral activities of M2 macrophages by a RAGE-dependent mechanism
Rojas, Armando ; Delgado-López, Fernando; Pérez-Castro, Ramón; González-Bonet, Ileana; Romero, Jacqueline; Rojas, Israel; Araya, Paulina; Morales-Mejías, Erik; Llano, Jorge; Añazco-Oyarzún, Carolina (2016)The monocyte-macrophage lineage shows a high degree of diversity and plasticity. Once they infiltrate tissues,they may acquire two main functional phenotypes, being known as the classically activated type 1 macrophages ...
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Inhibition of RAGE Axis signaling: A pharmacological challenge
The Receptor for Advanced Glycation End Products (RAGE) is an important cell surface receptor, which belongs to the IgG super family and is now considered as a pattern recognition receptor. Because of its relevance in many ...
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Lysyl oxidase isoforms in gastric cancer
Delgado-López, Fernando; Araya, Paulina; González-Bonet, Ileana; Morales-Mejías, Erik; Pérez-Castro, Ramón; Romero, Jacqueline; Rojas, Armando ; Añazco-Oyarzún, Carolina (2016)Gastric cancer (GC) is the fifth most frequent cancer in the world and shows the highest incidence in Latin America and Asia. An increasing amount of evidence demonstrates that lysyl oxidase isoforms, a group of extracellular ...
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M2 macrophages do not fly into a “RAGE”
Tumor-associated macrophages (TAMs) are key elements in orchestrating host responses inside tumor stroma. This population may undergo a polarized activation process, thus rendering a heterogeneous spectrum of phenotypes, ...
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Pattern recognition receptors and their roles in the host response to helicobacter pylori infection
Gonzalez, Ileana; Araya, Paulina; Schneider, Iván; Lindner-Sanhueza, Cristian; Rojas, Armando (2021)Helicobacter pylori (H. pylori) infection is highly prevalent, affecting 4.4 billion people globally. This pathogen is a risk factor in the pathogenesis of more than 75% of worldwide cases of gastric cancer. Pattern ...
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RID: Evaluation of the possible inhibiting effect of the proinflammatory signaling induced by TNF-α through NF-κβ and AP-1 in two cell lines of breast cancer
Monsalve, Francisco A.; Rojas, Armando ; González-Bonet, Ileana; Pérez-Castro, Ramón; Añazco-Oyarzún, Carolina; Romero, Jacqueline; Araya, Paulina; Santos, Leonardo S.; Delgado-López, Fernando (2020)Receptor internalization and degradation (RID), is a transmembrane protein coded within the E3 region expression cassette of adenoviruses. RID downregulates the cell surface expression of epidermal growth factor receptor ...
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RID: evaluation of the possible inhibiting effect of the proinflammatory signaling induced by TNF-α through NF-κβ and AP-1 in two cell lines of breast cancer
Monsalve, Francisco A.; Rojas, Armando ; Gonzalez, Ileana; Perez, Ramón; Añasco, Carolina; Romero, Jacqueline; Araya, Paulina; Santos, Leonardo S.; Delgado-López, Fernando (2020)Receptor internalization and degradation (RID), is a transmembrane protein coded within the E3 region expression cassette of adenoviruses. RID downregulates the cell surface expression of epidermal growth factor receptor ...
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Skewed signaling through the receptor for advanced glycation end-products alters the proinflammatory profile of tumor-associated macrophages
Rojas, Armando ; Araya, Paulina; Romero, Jacqueline; Delgado-López, Fernando; González-Bonet, Ileana; Añazco-Oyarzún, Carolina; Pérez-Castro, Ramón (2018)Tumors are complex tissues composed of variable amounts of both non-cellular components (matrix proteins) and a multitude of stromal cell types, which are under an active cross-talk with tumor cells. Tumor-associated ...