Now showing items 1-5 of 5

  • Chlorogenic acid inhibits human platelet activation and thrombus formation 

    Rojas, Armando ORCID; Fuentes, Eduardo; Caballero, Julio; Alarcón, Marcelo; Palomo, Iván (2014)
    Background: Chlorogenic acid is a potent phenolic antioxidant. However, its effect on platelet aggregation, a critical factor in arterial thrombosis, remains unclear. Consequently, chlorogenic acid-action mechanisms in ...

  • El consumo de frutas y hortalizas ayuda a prevenir el daño endotelial 

    Palomo, Iván; Fuentes, Eduardo; Moore-Carrasco, Rodrigo; González, Daniel R.; Rojas, Armando ORCID; Padro, Teresa; Badimon, Lina (2011)
    The endothelium helps to maintain the normal structure and homeostasis of the vasculature. However, chronic exposure to cardiovascular (CV) risk factors causes endothelial dysfunction, a phenomenon that is characterized ...

  • Cross-talk between platelet and tumor microenvironment: Role of multiligand/RAGE axis in platelet activation 

    Rojas, Armando ORCID; Fuentes, Eduardo; Palomo, Iván (2016)
    While platelets are well known to play a central role in hemostasis and thrombosis, there is emerging experimental evidence to suggest that they also mediate tumor cell growth, angiogenesis and metastasis. The receptor for ...

  • NF-κB signaling pathway as target for antiplatelet activity 

    Rojas, Armando ORCID; Fuentes, Eduardo; Palomo, Iván (2016)
    In different nucleated cells, NF-κB has long been considered a prototypical proinflammatory signaling pathway with the expression of proinflammatory genes. Although platelets lack a nucleus, a number of functional ...

  • Role of multiligand/RAGE axis in platelet activation 

    Rojas, Armando ORCID; Fuentes, Eduardo; Palomo, Iván (2014)
    In the context of plaque progression, platelet hyperactivity associated with hyperlipidemia contributes to the development of a pro-thrombotic state. In this context, it has been demonstrated that advanced glycation end ...