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Aerobic capacity of chilean adults and elderly: proposal of classification by regional percentiles
Urzua-Alul, Luis; Gómez-Campos, Rossana; Almonacid-Fierro, Alejandro; Morales-Mora, Lisbetty; Rojas-Mancilla, Edgardo; Palomo, Iván; Mendez-Cornejo, Jorge; Leite Portella, D.; Cossio-Bolaños, Marco Antonio (2019)Introducción: La aptitud aeróbica es un importante predictor que contribuye con la preservación de la independencia funcional a medida que se envejece. Su medición se transforma en una herramienta fundamental en la ...
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Chlorogenic acid inhibits human platelet activation and thrombus formation
Background: Chlorogenic acid is a potent phenolic antioxidant. However, its effect on platelet aggregation, a critical factor in arterial thrombosis, remains unclear. Consequently, chlorogenic acid-action mechanisms in ...
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El consumo de frutas y hortalizas ayuda a prevenir el daño endotelial
Palomo, Iván; Fuentes, Eduardo; Moore-Carrasco, Rodrigo; González, Daniel R.; Rojas, Armando ; Padro, Teresa; Badimon, Lina (2011)The endothelium helps to maintain the normal structure and homeostasis of the vasculature. However, chronic exposure to cardiovascular (CV) risk factors causes endothelial dysfunction, a phenomenon that is characterized ...
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Cross-talk between platelet and tumor microenvironment: Role of multiligand/RAGE axis in platelet activation
While platelets are well known to play a central role in hemostasis and thrombosis, there is emerging experimental evidence to suggest that they also mediate tumor cell growth, angiogenesis and metastasis. The receptor for ...
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NF-κB signaling pathway as target for antiplatelet activity
In different nucleated cells, NF-κB has long been considered a prototypical proinflammatory signaling pathway with the expression of proinflammatory genes. Although platelets lack a nucleus, a number of functional ...
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Role of multiligand/RAGE axis in platelet activation
In the context of plaque progression, platelet hyperactivity associated with hyperlipidemia contributes to the development of a pro-thrombotic state. In this context, it has been demonstrated that advanced glycation end ...