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Alzheimer's disease susceptibility gene Apolipoprotein E (APOE) and blood biomarkers in UK Biobank (N = 395,769)
Ferguson, Amy C.; Tank, Rachana; Lyall, Laura M.; Ward, Joey; Celis-Morales, Carlos; Strawbridge, Rona; Ho, Frederick; Whelan, Christopher D.; Gill, Jason M.R.; Welsh, Paul; Anderson, Jana J.; Mark, Patrick B.; Mackay, Daniel; Smith, Daniel J.; Pell, J.P.; Cavanagh, Jonathan; Sattar, Naveed; Lyall, Donald (2020)Background: Alzheimer's disease (AD) is a neurodegenerative condition where the underlying etiology is still unclear. Investigating the potential influence of apolipoprotein E (APOE), a major genetic risk factor, on common ...
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Anxiety disorder, depression and coronary artery disease: associations and modification by genetic susceptibility
Nakada, Shinya; Ward, Joey; Strawbridge, Rona J.; Welsh, Paul; Celis-Morales, Carlos; Ho, Frederick K.; Pell, Jill P. (2025)Background Associations of anxiety disorder and depression with coronary artery disease (CAD) are heterogeneous between populations. This study investigated how genetic susceptibility to CAD alters these associations with ...
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Genetic predisposition to adiposity, and type 2 diabetes: the role of lifestyle and phenotypic adiposity
Zhang, Mengrong; Ward, Joey; Strawbridge, Rona J.; Anderson, Jana J.; Celis-Morales, Carlos; Pell, Jill P.; Ho, Frederick K.; Lyall, Donald M (2025)Aims Genetic predisposition to adiposity is associated with type 2 diabetes (T2D), even in the absence of phenotypic adiposity (obesity and central obesity). We aimed to quantify the overall contribution of obesity and ...
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How do lifestyle factors modify the association between genetic predisposition and obesity-related phenotypes? a 4-way decomposition analysis using UK Biobank
Zhang, Mengrong; Ward, Joey; Strawbridge, Rona; Celis-Morales, Carlos; Pell, Jill P.; Lyall, Donald; Ho, Frederick (2024)Background Obesity and central obesity are multifactorial conditions with genetic and non-genetic (lifestyle and environmental) contributions. There is incomplete understanding of whether lifestyle modifies the translation ...