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Mostrando publicaciones 1-5 de 5
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Conotoxins as tools to understand the physiological function of voltage-gated calcium (CaV) channels
Ramírez, David; Gonzalez, Wendy; Fissore, Rafael A.; Carvacho-Contreras, Ingrid (2017)Voltage-gated calcium (CaV) channels are widely expressed and are essential for the completion of multiple physiological processes. Close regulation of their activity by specific inhibitors and agonists become fundamental ...
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Deletion of TRPV3 and CaV3.2 T-type channels in mice undermines fertility and Ca2+ homeostasis in oocytes and eggs
Mehregan, Aujan; Ardestani, Goli; Akizawa, Hiroki; Carvacho-Contreras, Ingrid; Fissore, Rafael A. (2021)Ca2+ influx during oocyte maturation and after sperm entry is necessary to fill the internal Ca2+ stores and for complete egg activation. We knocked out the transient receptor potential vanilloid member 3 (TRPV3) and the ...
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Divalent cation influx and calcium homeostasis in germinal vesicle mouse oocytes
Ardestani, Goli; Mehregan, Aujan; Fleig, Andrea; Horgen, F. David; Carvacho-Contreras, Ingrid; Fissore, Rafael A. (2020)Prior to maturation, mouse oocytes are arrested at the germinal vesicle (GV) stage during which they experience constitutive calcium (Ca2+) influx and spontaneous Ca2+ oscillations. The oscillations cease during maturation ...
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Essential role of Mg2+ in mouse preimplantation embryo development revealed by TRPM7 chanzymedeficient gametes
Gupta, Neha; Soriano-Úbeda, Paula Stein; Alfandari, Dominique; Williams, Carmen J.; Fissore, Rafael A. (2023) -
TRPM7-like channels are functionally expressed in oocytes and modulate post-fertilization embryo development in mouse
Carvacho-Contreras, Ingrid; Ardestani, Goli; Lee, Hoi Chang; McGarvey, Kaitlyn; Fissore, Rafael A.; Lykke-Hartmann, Karin (2016)The Transient Receptor Potential (TRP) channels are a family of cationic ion channels widely distributed in mammalian tissues. In general, the global genetic disruption of individual TRP channels result in phenotypes ...