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Mostrando publicaciones 1-9 de 9
M2 macrophages do not fly into a “RAGE”
(2017)
Tumor-associated macrophages (TAMs) are key elements in orchestrating host responses inside tumor stroma. This population may undergo a polarized activation process, thus rendering a heterogeneous spectrum of phenotypes, ...
Dermal collagen stabilization by polyphenols and spray drying as an encapsulation strategy
(2018)
Collagen, the most abundant component in mammalian tissues, has a crucial impact at skin level. Both promotion and maintenance of cross-linked collagen at the skin are critical to sustain the functionality and appearance ...
HMGB1 enhances the protumoral activities of M2 macrophages by a RAGE-dependent mechanism
(2016)
The monocyte-macrophage lineage shows a high degree of diversity and plasticity. Once they infiltrate tissues,they may acquire two main functional phenotypes, being known as the classically activated type 1 macrophages ...
Skewed signaling through the receptor for advanced glycation end-products alters the proinflammatory profile of tumor-associated macrophages
(2018)
Tumors are complex tissues composed of variable amounts of both non-cellular components (matrix proteins) and a multitude of stromal cell types, which are under an active cross-talk with tumor cells. Tumor-associated ...
Lysyl oxidase isoforms in gastric cancer
(2016)
Gastric cancer (GC) is the fifth most frequent cancer in the world and shows the highest incidence in Latin America and Asia. An increasing amount of evidence demonstrates that lysyl oxidase isoforms, a group of extracellular ...
Extracellular matrix glycation and receptor for advanced glycation end-products activation: A missing piece in the puzzle of the association between diabetes and cancer
(2018)
A growing body of epidemiologic evidence suggests that people with diabetes are at a significantly higher risk of many forms of cancer. However, the molecular mechanisms underlying this association are not fully understood. ...
HMGB1 decreases CCR-2 expression and migration of M2 macrophages under hypoxia
(2019)
Objective: The hypoxic milieu at tumor microenvironment is able to drive the behavior of infiltrating tumor cells. Considering that hypoxia-mediated HMGB1 release is known to promote tumor growth, as well to enhance the ...
RID: Evaluation of the possible inhibiting effect of the proinflammatory signaling induced by TNF-α through NF-κβ and AP-1 in two cell lines of breast cancer
(2020)
Receptor internalization and degradation (RID), is a transmembrane protein coded within the E3 region expression cassette of adenoviruses. RID downregulates the cell surface expression of epidermal growth factor receptor ...
Exploring the interplay between polyphenols and lysyl oxidase enzymes for maintaining extracellular matrix homeostasis
(2023)
Collagen, the most abundant structural protein found in mammals, plays a vital role as
a constituent of the extracellular matrix (ECM) that surrounds cells. Collagen fibrils are strengthened
through the formation of ...