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The receptor for advanced glycation end-products: A complex signaling scenario for a promiscuous receptor
Firstly described in 1992, the receptor for advanced glycation end-products has attracted increasing attention due to its diverse ligand repertoire and involvement in several pathophysiological processes associated with ...
HMGB1 enhances the protumoral activities of M2 macrophages by a RAGE-dependent mechanism
The monocyte-macrophage lineage shows a high degree of diversity and plasticity. Once they infiltrate tissues,they may acquire two main functional phenotypes, being known as the classically activated type 1 macrophages ...
Skewed signaling through the receptor for advanced glycation end-products alters the proinflammatory profile of tumor-associated macrophages
Tumors are complex tissues composed of variable amounts of both non-cellular components (matrix proteins) and a multitude of stromal cell types, which are under an active cross-talk with tumor cells. Tumor-associated ...
Lysyl oxidase isoforms in gastric cancer
Gastric cancer (GC) is the fifth most frequent cancer in the world and shows the highest incidence in Latin America and Asia. An increasing amount of evidence demonstrates that lysyl oxidase isoforms, a group of extracellular ...
The emerging role of the receptor for advanced glycation end products on innate immunity
Cells from innate immune system are activated by the engagement of germ-line encoded patternrecognition receptors (PRRs) in response to the microbial insult. These receptors are able to recognize either the presence of ...