Now showing items 1-6 of 6
M2 macrophages do not fly into a “RAGE”
Tumor-associated macrophages (TAMs) are key elements in orchestrating host responses inside tumor stroma. This population may undergo a polarized activation process, thus rendering a heterogeneous spectrum of phenotypes, ...
Dermal collagen stabilization by polyphenols and spray drying as an encapsulation strategy
Collagen, the most abundant component in mammalian tissues, has a crucial impact at skin level. Both promotion and maintenance of cross-linked collagen at the skin are critical to sustain the functionality and appearance ...
HMGB1 enhances the protumoral activities of M2 macrophages by a RAGE-dependent mechanism
The monocyte-macrophage lineage shows a high degree of diversity and plasticity. Once they infiltrate tissues,they may acquire two main functional phenotypes, being known as the classically activated type 1 macrophages ...
Skewed signaling through the receptor for advanced glycation end-products alters the proinflammatory profile of tumor-associated macrophages
Tumors are complex tissues composed of variable amounts of both non-cellular components (matrix proteins) and a multitude of stromal cell types, which are under an active cross-talk with tumor cells. Tumor-associated ...
Lysyl oxidase isoforms in gastric cancer
Gastric cancer (GC) is the fifth most frequent cancer in the world and shows the highest incidence in Latin America and Asia. An increasing amount of evidence demonstrates that lysyl oxidase isoforms, a group of extracellular ...
Extracellular matrix glycation and receptor for advanced glycation end-products activation: A missing piece in the puzzle of the association between diabetes and cancer
A growing body of epidemiologic evidence suggests that people with diabetes are at a significantly higher risk of many forms of cancer. However, the molecular mechanisms underlying this association are not fully understood. ...