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HMGB1 enhances the protumoral activities of M2 macrophages by a RAGE-dependent mechanism
The monocyte-macrophage lineage shows a high degree of diversity and plasticity. Once they infiltrate tissues,they may acquire two main functional phenotypes, being known as the classically activated type 1 macrophages ...
The emerging role of the receptor for advanced glycation end products on innate immunity
Cells from innate immune system are activated by the engagement of germ-line encoded patternrecognition receptors (PRRs) in response to the microbial insult. These receptors are able to recognize either the presence of ...
Extracellular matrix glycation and receptor for advanced glycation end-products activation: A missing piece in the puzzle of the association between diabetes and cancer
A growing body of epidemiologic evidence suggests that people with diabetes are at a significantly higher risk of many forms of cancer. However, the molecular mechanisms underlying this association are not fully understood. ...