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The receptor for advanced glycation end-products: A complex signaling scenario for a promiscuous receptor
(2013)
Firstly described in 1992, the receptor for advanced glycation end-products has attracted increasing attention due to its diverse ligand repertoire and involvement in several pathophysiological processes associated with ...
HMGB1 enhances the protumoral activities of M2 macrophages by a RAGE-dependent mechanism
(2016)
The monocyte-macrophage lineage shows a high degree of diversity and plasticity. Once they infiltrate tissues,they may acquire two main functional phenotypes, being known as the classically activated type 1 macrophages ...
The emerging role of the receptor for advanced glycation end products on innate immunity
(2014)
Cells from innate immune system are activated by the engagement of germ-line encoded patternrecognition receptors (PRRs) in response to the microbial insult. These receptors are able to recognize either the presence of ...