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HMGB1 decreases CCR-2 expression and migration of M2 macrophages under hypoxia

Araya, Paulina; Romero, Jacqueline; Delgado-López, Fernando; Gonzalez, Ileana; Añazco-Oyarzún, Carolina; Perez, Ramón; Rojas, Armando (2019)

Objective: The hypoxic milieu at tumor microenvironment is able to drive the behavior of infiltrating tumor cells. Considering that hypoxia-mediated HMGB1 release is known to promote tumor growth, as well to enhance the ...