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Iron-induced pro-oxidant and pro-lipogenic responses in relation to impaired synthesis and accretion of long-chain polyunsaturated fatty acids in rat hepatic and extrahepatic tissues

dc.contributor.authorOrtiz-Manrique, Macarena
dc.contributor.authorValenzuela, Rodrigo
dc.contributor.authorRincón-Cervera, Miguel Ángel
dc.contributor.authorEcheverría, Francisca
dc.contributor.authorBarrera, Cynthia
dc.contributor.authorEspinosa, Alejandra
dc.contributor.authorHernández-Rodas, María Catalina
dc.contributor.authorValenzuela, Alfonso
dc.contributor.authorVidela, Luis A.
dc.date.accessioned2017-10-30T15:35:01Z
dc.date.available2017-10-30T15:35:01Z
dc.date.issued2018
dc.identifier.urihttp://repositorio.ucm.cl/handle/ucm/950
dc.description.abstractObjectives: Iron is involved in processes involving oxygen transfer and utilization. Excess iron is linked to cardiovascular diseases and some types of cancer. Iron overload is associated with oxidative stress development, and may have important interactions with lipid metabolism in the liver favoring the development and progression of non-alcoholic fatty liver disease. The aim of the study described here was to assess the effect of high intake of iron on oxidative stress-related parameters, lipid metabolism, and levels of long-chain polyunsaturated fatty acids (LCPUFAs) in liver and other tissues of the rat. Methods: Male Wistar rats (21 d old) were fed an iron-rich diet (200 mg iron/kg diet, IRD) versus a control diet (50 mg iron/kg diet; CD) for 21 d. Samples of erythrocytes, liver, adipose tissue, brain, heart, and testicles were evaluated for fatty acid composition and hepatic biochemical and oxidative stress parameters, D-6 and D-5 desaturase activities, SREBP-1c and PPAR-a mRNA expression and DNA-binding capacity, and lipolytic, lipogenic, and antioxidant enzymatic activities. Results: The IRD caused liver steatosis and increased activity of plasma transaminases, with higher oxidative stress status in plasma and liver. Liver D-6 and D-5 desaturase exhibited decreased activity, but enhanced expression in response to the IRD compared with the CD, with lower levels of u-3 and u-6 LCPUFAs and higher expression and DNA binding of SREBP-1c, whereas expression and DNA-binding activity of PPAR-a were diminished. Conclusions: IRD induced oxidative stress and a reduction in the desaturation capacity of the liver, with LCPUFA depletion in the different tissues studied, thus promoting a pro-steatotic condition in the liver.es_CL
dc.language.isoenes_CL
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
dc.sourceNutrition, 45, 49-58es_CL
dc.subjectIrones_CL
dc.subjectOxidative stresses_CL
dc.subjectTissue long-chain polyunsaturated fatty acid metabolismes_CL
dc.subjectLiver D-6/D-5 desaturase activityes_CL
dc.titleIron-induced pro-oxidant and pro-lipogenic responses in relation to impaired synthesis and accretion of long-chain polyunsaturated fatty acids in rat hepatic and extrahepatic tissueses_CL
dc.typeArticlees_CL
dc.ucm.facultadFacultad de Ciencias de la Saludes_CL
dc.ucm.indexacionScopuses_CL
dc.ucm.indexacionIsies_CL
dc.ucm.urisibib2.ucm.cl:2048/login?url=https://www.sciencedirect.com/science/article/pii/S0899900717301533es_CL
dc.ucm.doidoi.org/10.1016/j.nut.2017.07.007es_CL


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Atribución-NoComercial-SinDerivadas 3.0 Chile
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