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RGD-binding integrins and TGF-β in SARS-CoV-2 infections – novel targets to treat COVID-19 patients?

dc.contributor.authorCarvacho-Contreras, Ingrid
dc.contributor.authorPiesche, Matthias
dc.date.accessioned2021-12-29T11:45:56Z
dc.date.available2021-12-29T11:45:56Z
dc.date.issued2021
dc.identifier.urihttp://repositorio.ucm.cl/handle/ucm/3680
dc.description.abstractThe new coronavirus SARS-CoV-2 is a global pandemic and a severe public health crisis. SARS-CoV-2 is highly contagious and shows high mortality rates, especially in elderly and patients with pre-existing medical conditions. At the current stage, no effective drugs are available to treat these patients. In this review, we analyse the rationale of targeting RGD-binding integrins to potentially inhibit viral cell infection and to block TGF-β activation, which is involved in the severity of several human pathologies, including the complications of severe COVID-19 cases. Furthermore, we demonstrate the correlation between ACE2 and TGF-β expression and the possible consequences for severe COVID-19 infections. Finally, we list approved drugs or drugs in clinical trials for other diseases that also target the RGD-binding integrins or TGF-β. These drugs have already shown a good safety profile and, therefore, can be faster brought into a trial to treat COVID-19 patients.es_CL
dc.language.isoenes_CL
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
dc.sourceClinical & Translational Immunology, 10, e1240es_CL
dc.subjectCOVID-19es_CL
dc.subjectRGD-binding integrinses_CL
dc.subjectTGF-βes_CL
dc.subjectInflammationes_CL
dc.subjectARDSes_CL
dc.subjectCytokineses_CL
dc.titleRGD-binding integrins and TGF-β in SARS-CoV-2 infections – novel targets to treat COVID-19 patients?es_CL
dc.typeArticlees_CL
dc.ucm.facultadFacultad de Medicinaes_CL
dc.ucm.indexacionScopuses_CL
dc.ucm.indexacionIsies_CL
dc.ucm.urionlinelibrary.wiley.com/doi/10.1002/cti2.1240es_CL
dc.ucm.doidoi.org/10.1002/cti2.1240es_CL


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