Introduction: The "INTEGRA" methodology represents an updated approach for integrative reviews, emphasizing the quality of outcomes in response to a need expressed by the scientific community. Objective: To present the INTEGRA methodology and provide guidelines and recommendations for its application. Methods: This methodological study was conducted in two stages: a) Development of the guideline and b) Analysis. The study was carried out by a team of experts from Chile, Colombia, Mexico, Costa Rica, and Brazil, who met at least one of the following criteria: a) holding a doctoral degree or being a doctoral candidate with experience in conducting literature reviews; b) having experience in developing reviews for or with professionals in clinical-care settings, policymakers, government agencies, or other decision-makers. Results: The "INTEGRA" methodology consists of seven stages: 1. (I) Idea or study problem; 2. (N) Narrowing down the inquiry or objective; 3. (T) Targeting the search strategy; 4. (E) Execution or implementation of the search; 5. (G) Grading and quality control of the results; 6. (R) Reviewing the results; 7. (A) Analysis and discussion. Conclusions: The application of the "INTEGRA" methodology will provide authors with guidelines for developing integrative reviews and improving the quality of contributions in this field.