Ver publicación 

Mostrar el registro sencillo de la publicación

In people with type 2 diabetes, sarcopenia is associated with the incidence of cardiovascular disease: a prospective cohort study from the UK Biobank

dc.contributor.authorBoonpor, Jirapitcha
dc.contributor.authorPell, Jill P.
dc.contributor.authorHo, Frederick
dc.contributor.authorCelis-Morales, Carlos
dc.contributor.authorGray, Stuart R.
dc.date.accessioned2025-03-17T18:15:48Z
dc.date.available2025-03-17T18:15:48Z
dc.date.issued2024
dc.identifier.urihttp://repositorio.ucm.cl/handle/ucm/5857
dc.description.abstractAim: To investigate the association of sarcopenia with cardiovascular disease (CVD)incidence in people with type 2 diabetes.Materials and Methods: A prospective cohort study with 11 974 White EuropeanUK Biobank participants with type 2 diabetes, aged 40-70 years, included. Sarcope-nia was defined based on the European Working Group on Sarcopenia in Older Peo-ple as either non-sarcopenic or sarcopenic. Outcomes included CVD, stroke, heartfailure (HF) and myocardial infarction (MI). The association between sarcopenia andthe incidence of outcomes was investigated using Cox proportional hazard modelsadjusted for sociodemographic and lifestyle factors. The rate advancement periodwas used to estimate the time period by which CVD is advanced because ofsarcopenia.Results: Over a median follow-up of 10.7 years, 1957 participants developed CVDs:373 had a stroke, 307 had an MI and 742 developed HF. Compared with non-sarcopenia, those with sarcopenia had higher risks of CVD (HR 1.89 [95% CI 1.61;2.21]), HF (HR 2.59 [95% CI 2.12; 3.18]), stroke (HR 1.90 [95% CI 1.38; 2.63]), andMI (HR 1.56 [95% CI 1.04; 2.33]) after adjustment for all covariates. Those with sar-copenia had CVD incidence rates equivalent to those without sarcopenia who were14.5 years older. Similar results were found for stroke, HF and MI.Conclusions: In people with type 2 diabetes, sarcopenia increased the risk of devel-oping CVD, which might occur earlier than in those without sarcopenia. Therefore,sarcopenia screening and prevention in patients with type 2 diabetes may be usefulto prevent the complications of CVD.es_CL
dc.language.isoenes_CL
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
dc.sourceDiabetes, Obesity and Metabolism, 26(2), 524-531es_CL
dc.subjectGait speedes_CL
dc.subjectHand strengthes_CL
dc.subjectHeart diseaseses_CL
dc.subjectMuscle mass indexes_CL
dc.subjectSkeleton musclees_CL
dc.subjectType 2 diabeteses_CL
dc.titleIn people with type 2 diabetes, sarcopenia is associated with the incidence of cardiovascular disease: a prospective cohort study from the UK Biobankes_CL
dc.typeArticlees_CL
dc.ucm.indexacionScopuses_CL
dc.ucm.indexacionIsies_CL
dc.ucm.uridom-pubs.pericles-prod.literatumonline.com/doi/epdf/10.1111/dom.15338es_CL
dc.ucm.doidoi.org/10.1111/dom.15338es_CL


Ficheros en la publicación

FicherosTamañoFormatoVer

No hay ficheros asociados a esta publicación.

Esta publicación aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo de la publicación

Atribución-NoComercial-SinDerivadas 3.0 Chile
Excepto si se señala otra cosa, la licencia de la publicación se describe como Atribución-NoComercial-SinDerivadas 3.0 Chile