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You are as old as the connectivity you keep: distinct neurophysiological mechanisms underlying age-related changes in hand dexterity and strength

dc.contributor.authorChiappini, Emilio
dc.contributor.authorTurrini, Sonia
dc.contributor.authorFiori, Francesca
dc.contributor.authorBenassi, Mariagrazia
dc.contributor.authorTessari, Alessia
dc.contributor.authordi Pellegrino, Giuseppe
dc.contributor.authorAvenanti, Alessio
dc.date.accessioned2025-03-26T12:44:08Z
dc.date.available2025-03-26T12:44:08Z
dc.date.issued2025
dc.identifier.urihttp://repositorio.ucm.cl/handle/ucm/5884
dc.description.abstractBackground Aging can lead to a decline in motor control. While age-related motor impairments have been documented, the underlying changes in cortico-cortical interactions remain poorly understood. Methods We took advantage of the high temporal resolution of dual-site transcranial magnetic stimulation (dsTMS) to investigate how communication between higher-order rostral premotor regions and the primary motor cortex (M1) influences motor control in young and elderly adults. We assessed the dynamics of connectivity from the inferior frontal gyrus (IFG) or pre-supplementary motor area (preSMA) to M1, by testing how conditioning of the IFG/preSMA affected the amplitude of motor evoked potentials (MEPs) induced by M1 stimulation at different temporal intervals. Moreover, we explored how age-related changes in premotor-M1 interactions relate to motor performance. Results Our results show that both young and elderly adults had excitatory IFG-M1 and preSMA-M1 interactions, but the two groups’ timing and strength differed. In young adults, IFG-M1 interactions were early and time-specific (8 ms), whereas in older individuals, they were delayed and more prolonged (12-16 ms). PreSMA-M1 interactions emerged early (6 ms) and peaked at 10-12 ms in young individuals but were attenuated in older individuals. Critically, a connectivity profile of the IFG-M1 circuit like that of the young cohort predicted better dexterity in older individuals, while preserved preSMA-M1 interactions predicted greater strength, suggesting that age-related motor decline is associated with specific changes in premotor-motor networks. Conclusions Preserving youthful motor network connectivity in older individuals is related to maintaining motor performance and providing information for interventions targeting aging effects on behavior.es_CL
dc.language.isoenes_CL
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
dc.sourceArchives of Medical Research, 56(1), 103031es_CL
dc.subjectAginges_CL
dc.subjectBrain connectomees_CL
dc.subjectPremotor cortexes_CL
dc.subjectTranscranial magnetic stimulationes_CL
dc.subjectHand strengthes_CL
dc.subjectMotor skillses_CL
dc.titleYou are as old as the connectivity you keep: distinct neurophysiological mechanisms underlying age-related changes in hand dexterity and strengthes_CL
dc.typeArticlees_CL
dc.ucm.indexacionScopuses_CL
dc.ucm.indexacionIsies_CL
dc.ucm.urisciencedirect.ucm.elogim.com/science/article/pii/S0188440924000833?via%3Dihubes_CL
dc.ucm.doidoi.org/10.1016/j.arcmed.2024.103031es_CL


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Atribución-NoComercial-SinDerivadas 3.0 Chile
Excepto si se señala otra cosa, la licencia de la publicación se describe como Atribución-NoComercial-SinDerivadas 3.0 Chile