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Anxiety disorder, depression and coronary artery disease: associations and modification by genetic susceptibility

dc.contributor.authorNakada, Shinya
dc.contributor.authorWard, Joey
dc.contributor.authorStrawbridge, Rona J.
dc.contributor.authorWelsh, Paul
dc.contributor.authorCelis-Morales, Carlos
dc.contributor.authorHo, Frederick K.
dc.contributor.authorPell, Jill P.
dc.date.accessioned2025-04-09T13:58:50Z
dc.date.available2025-04-09T13:58:50Z
dc.date.issued2025
dc.identifier.urihttp://repositorio.ucm.cl/handle/ucm/5932
dc.description.abstractBackground Associations of anxiety disorder and depression with coronary artery disease (CAD) are heterogeneous between populations. This study investigated how genetic susceptibility to CAD alters these associations with incident CAD, comparing and combining anxiety disorder and depression. Methods This is a prospective cohort study using UK Biobank. Diagnoses of anxiety disorder and depression were ascertained through linked hospital admission data. Incident CAD was ascertained through hospital admission and death certificate data after baseline. CAD polygenic risk score (PRSCAD) was obtained from CARDIoGRAMplus4 and categorised into low, intermediate, and high. Cox proportional hazard models were used to examine associations between anxiety disorder and depression and CAD. Results Both anxiety disorder (HR 2.31, 95% CI 1.92–2.78) and depression (HR 2.15, 95% CI 1.90–2.24) were associated with CAD after adjusting for sociodemographic confounders. There was an addictive interaction between depression and PRSCAD (RERI 0.97, 95% CI 0.12–1.81) such that the association between depression and CAD was strongest among those with a high PRSCAD whilst there was no such evidence for anxiety disorder. Anxiety disorder only (HR 1.68, 95% 1.16–2.44), depression only (HR 2.13, 95% CI 1.72–2.64), and concomitant anxiety disorder and depression (HR 3.85, 95% CI 2.48–5.98) were associated with CAD even among people with a low PRSCAD. Adjusting for potential mediators attenuated all these associations across PRS categories. Conclusions CAD genetic susceptibility might partly contribute to the clustering of depression and CAD but does not provide a full explanation, nor does it explain the association between anxiety disorder and CAD. Therefore, other mechanisms should be explored.es_CL
dc.language.isoenes_CL
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
dc.sourceBMC Medicine, 23(1), 73es_CL
dc.subjectDepressiones_CL
dc.subjectAnxietyes_CL
dc.subjectCoronary artery diseasees_CL
dc.titleAnxiety disorder, depression and coronary artery disease: associations and modification by genetic susceptibilityes_CL
dc.typeArticlees_CL
dc.ucm.indexacionScopuses_CL
dc.ucm.indexacionIsies_CL
dc.ucm.uribmcmedicine.biomedcentral.com/articles/10.1186/s12916-025-03915-4es_CL
dc.ucm.doidoi.org/10.1186/s12916-025-03915-4es_CL


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