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High temperature induces oxidative damage, immune modulation, and atrophy in the gills and skeletal muscle of the teleost fish black cusk-eel (Genypterus maculatus)

dc.contributor.authorBecerra, Sofia
dc.contributor.authorArriagada-Solimano, Marcia
dc.contributor.authorEscobar-Aguirre, Sebastian
dc.contributor.authorPalomino, Jaime
dc.contributor.authorAedo, Jorge
dc.contributor.authorEstrada, Juan Manuel
dc.contributor.authorBarra-Valdebenito, Veronica
dc.contributor.authorZuloaga, Rodrigo
dc.contributor.authorValdes, Juan Antonio
dc.contributor.authorDettleff, Phillip
dc.date.accessioned2025-05-07T13:59:26Z
dc.date.available2025-05-07T13:59:26Z
dc.date.issued2025
dc.identifier.urihttp://repositorio.ucm.cl/handle/ucm/6032
dc.description.abstractThe high temperature associated with heat waves is a relevant abiotic factor that could impact the biology of teleost fish. The innate immune response, muscular growth, and oxidative stress status are relevant functions in fish tissues that could be affected by increased temperature. In this study, black cusk-eel (Genypterus maculatus) juveniles were subjected to increased temperature, to experimentally replicate heat waves registered from the South Pacific Ocean for five days. The results showed that thermal stress modulated the immune response in gills, with up-regulation of antibacterial peptides, pro-inflammatory cytokines, and Toll-like receptors genes, including hepcidin, gzma, tnfa, cxcl8, and tlr5, with no effect on complement system genes. In skeletal muscle, high temperature triggered atrophy-related gene expression, with up-regulation of foxo1, foxo3, fbxo32, murf1, and atg16l. Increased temperature also generated an up-regulation of transcripts encoding heat shock protein (hsp60 and hsp70) in gills and skeletal muscle, generating oxidative stress in both tissues, with increased expression of the antioxidant genes sod1 and gpx1 in gills and skeletal muscle, respectively, with oxidative damage observed at the DNA level (AP sites), protein (carbonyl content), and lipoperoxidation (HNE content) in both tissues. The present study shows that short-term increases in temperature like those observed in heat waves could affect the immune response in gills, induced atrophy in skeletal muscle, and generate oxidative stress in a teleost species important for Chilean aquaculture diversification, information relevant under the context of climate change scenario.es_CL
dc.language.isoenes_CL
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
dc.sourceDevelopmental and Comparative Immunology, 164, 105332es_CL
dc.subjectBlack cusk-eeles_CL
dc.subjectThermal stresses_CL
dc.subjectHeat waveses_CL
dc.subjectImmune responsees_CL
dc.subjectOxidative stresses_CL
dc.subjectAtrophyes_CL
dc.titleHigh temperature induces oxidative damage, immune modulation, and atrophy in the gills and skeletal muscle of the teleost fish black cusk-eel (Genypterus maculatus)es_CL
dc.typeArticlees_CL
dc.ucm.facultadFacultad de Ciencias Básicases_CL
dc.ucm.indexacionScopuses_CL
dc.ucm.indexacionIsies_CL
dc.ucm.urisciencedirect.ucm.elogim.com/science/article/pii/S0145305X25000217?via%3Dihubes_CL
dc.ucm.doidoi.org/10.1016/j.dci.2025.105332es_CL


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Atribución-NoComercial-SinDerivadas 3.0 Chile
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