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Dataset and analysis of genetic variability of severe acute Respiratory Syndrome Coronavirus 2 from different areas of the respiratory tract
| dc.contributor.author | Rojas-Pérez, Víctor Eduardo | |
| dc.contributor.author | Parra Villegas, Eduardo | |
| dc.date.accessioned | 2025-07-07T19:47:05Z | |
| dc.date.available | 2025-07-07T19:47:05Z | |
| dc.date.issued | 2025 | |
| dc.identifier.uri | http://repositorio.ucm.cl/handle/ucm/6211 | |
| dc.description.abstract | Shannon entropy data were obtained from whole genome sequences of SARS-CoV-2 virus from COVID-19 positive patients from nasopharyngeal and tracheal aspirate samples, these sequences were downloaded from the NCBI public database. The study included 57 genomic sequences of the SARS-CoV-2 virus. A total of 57 samples (n = 30 oronasopharyngeal and n = 27 tracheal aspirates) underwent bioinformatics-based analysis with the objective of determining the extent of viral variability. These sequences were used to perform a genetic variability analysis of the virus with the H(x) function of the BioEdit program and using the Wuhan-Hu-1 reference genome. The generated Shannon entropy data were filtered to comparatively determine the magnitudes of genetic variability between sequences from nasopharyngeal and tracheal aspirate samples using an R script. This paper proposes a workflow for the bionformatic analysis of SARS-CoV-2 genetic variation from different respiratory system samples. This bioinformatics workflow could help to differentiate changes in the evolution of the viral population in different compartments of the respiratory system. | es_CL |
| dc.language.iso | en | es_CL |
| dc.rights | Atribución-NoComercial-SinDerivadas 3.0 Chile | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | * |
| dc.source | MethodsX, 14, 103369 | es_CL |
| dc.subject | Genetic variants | es_CL |
| dc.subject | SARS-CoV-2 | es_CL |
| dc.subject | Genome | es_CL |
| dc.subject | Health | es_CL |
| dc.title | Dataset and analysis of genetic variability of severe acute Respiratory Syndrome Coronavirus 2 from different areas of the respiratory tract | es_CL |
| dc.type | Article | es_CL |
| dc.ucm.facultad | Facultad de Ciencias Agrarias y Forestales | es_CL |
| dc.ucm.indexacion | Scopus | es_CL |
| dc.ucm.uri | sciencedirect.ucm.elogim.com/science/article/pii/S2215016125002158?via%3Dihub | es_CL |
| dc.ucm.doi | doi.org/10.1016/j.mex.2025.103369 | es_CL |
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