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Mostrando publicaciones 1-13 de 13
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A computational approach to predict the role of genetic alterations in methyltransferase histones genes with implications in liver cancer
Aravena, Tania Isabella; Valdés, Elizabeth; D'Afonseca, Vívian (2023)Histone methyltransferases (HMTs) comprise a subclass of epigenetic regulators. Dysregulation of these enzymes results in aberrant epigenetic regulation, commonly observed in various tumor types, including hepatocellular ...
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Computational analyses on genetic alterations in the NSD genes family and the implications for colorectal cancer development
D'Afonseca, Vívian; Gónzalez, Glória; Salazar, Marcela; Arencibia-Rodríguez, Ariel (2020)Colorectal cancer (CRC) is a prevalent tumour throughout the world. CRC symptoms appear only in advanced stages causing decrease in survival of patients. Therefore, it is necessary to establish new strategies to detect CRC ...
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Current progress on the biodegradation of synthetic plastics: from fundamentals to biotechnological applications.
Andler-Osorio, Rodrigo; Tiso, Till; Blank, Lars; Andreeßen, Christina; Zampolli, Jessica; D'Afonseca, Vívian; Guajardo, Camila; Díaz-Barrera, Álvaro (2022)Plastic pollution is a global concern due to the long half-life and high resistance of many synthetic plastics to natural biodegradation. Therefore, great effort is required to avoid littering. However, the challenge of ...
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From proteome to potential drugs: integration of subtractive proteomics and ensemble docking for drug repurposing against Pseudomonas aeruginosa RND superfamily proteins
Urra, Gabriela; Valdés-Muñoz, Elizabeth; Suardiaz, Reynier; Hernández-Rodríguez, Erix W.; Palma, Jonathan M.; Ríos-Rozas, Sofía E.; Flores-Morales, Camila A.; Alegría-Arcos, Melissa; Yáñez, Osvaldo; Morales-Quintana, Luis; D’Afonseca, Vívian; Bustos, Daniel (2024)Pseudomonas aeruginosa (P. aeruginosa) poses a significant threat as a nosocomial pathogen due to its robust resistance mechanisms and virulence factors. This study integrates subtractive proteomics and ensemble docking ...
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Histone methyltransferases useful in gastric cancer research
Reyes, Dafne A.; Saure Sarría, Victor Manuel; Salazar, Marcela; D'Afonseca, Vívian (2021)Gastric cancer (GC) is one of the most frequent tumors in the world. Stomach adenocarcinoma is a heterogeneous tumor, turning the prognosis prediction and patients’ clinical management difficult. Some diagnosis tests for ...
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Identification of altered genes in gallbladder cancer as potential driver mutations for diagnostic and prognostic purposes: a computational approach
D'Afonseca, Vívian; Arencibia-Rodríguez, Ariel; Echeverría-Vega, Alex; Cerpa, Leslie; Cayún, Juan P.; Varela, Nelson M.; Salazar, Marcela; Quiñones, Luis A. (2020)Prognostic markers for cancer can assist in the evaluation of survival probability of patients and help clinicians to assess the available treatment modalities. Gallbladder cancer (GBC) is a rare tumor that causes 165 087 ...
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Implications of the microbiome and metabolic intermediaries produced by bacteria in breast cancer
D'Afonseca, Vívian; Valdés Muñoz, Elizabeth; López Leal, Alan; Suazo Soto, Patricio Maximiliano Adrián; Parra-Cid, Cristóbal (2024)The breast microbiome presents a diverse microbial community that could affects health and disease states, in the context of breast cancer. Sequencing technologies have allowed describing the diversity and abundance of ...
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Learning from transgenics: Advanced gene editing technologies should also bridge the gap with traditional genetic selection
Arencibia-Rodríguez, Ariel; D'Afonseca, Vívian; Chakravarthi, Mohan; Castiglione, Stefano (2019)We highlight the importance of the mixed genetic approaches (classical and currents) to improve the social perception related to the GMOs acceptance. We pointed out that CRISPR/Cas9 events could carry DNA variability/rea ...
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SARS-CoV-2 genetic and immunology insights: what does the scientific community know so far?
Cabrera Ayala, Macarena; Salazar-Viedma, M.; D'Afonseca, Vívian (2022)The challenge presented by the SARS-CoV-2 pathogen has changed the global perception about virus diseases. In Wuhan, China the first case of the disease called COVID-19 (Coronavirus Disease 2019) was reported in December ...
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Simulation model for Hashimoto autoimmune thyroiditis disease
Salazar, Marcela; Vergaño-Salazar, J. G.; Pastenes, Luis; D'Afonseca, Vívian (2021)Hashimoto thyroiditis (HT) is a pathology that often causes a gradual thyroid insufficiency in affected patients due to the autoimmune destruction of this gland. The cellular immune response mediated by T helper lymphocytes ...
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Transcriptome profiling of raspberry (Rubus idaeus Var. Amira) in response to infection by tomato ringspot virus (ToRSV)
González, Gloria; Aguilera, Felipe; D'Afonseca, Vívian (2020)Raspberry (Rubus sp.) is a berries fruit with an ongoing agricultural and commercial interest due to its high contents of flavonoids and nutrients beneficial for human health. The growing demand for raspberries is facing ...
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Validation of reference genes in a population of blueberry (vaccinium corymbosum) plants regenerated in colchicine
D'Afonseca, Vívian; Hernández, Ricardo; Gómez, Aleydis; Arencibia-Rodríguez, Ariel; Valenzuela-Valenzuela, Francisca (2022)For the first time we report the validation of reference genes in plants from a population of blueberry (Vaccinium corymbosum) clones cultured in vitro on a colchicine-supplemented medium. Nodal segment explants of the ...
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Xeloda oral, trastuzumab, and pertuzumab combined drug therapy reduced cervical lymphadenopathy and dermal involvement in patient with recurrent breast cancer: case report
Saure Sarría, Victor Manuel; Arencibia-Rodríguez, Ariel; D'Afonseca, Vívian (2020)We report the case of a 42-year-old woman who was diagnosed with breast cancer that recurred 3 years later, with supraclavicular lymphadenopathy and dermal involvement. The main drug used in the therapy was trastuzumab; ...