Listar por autor
Mostrando publicaciones 1-20 de 22
-
Advanced-glycation end-products axis: A contributor to the risk of severe illness from COVID-19 in diabetes patients
Compelling pieces of evidence derived from both clinical and experimental research has demonstrated the crucial role of the receptor for advanced-glycation end-products (RAGE) in orchestrating a plethora of proinflammatory ...
-
Contribution of RAGE axis activation to the association between metabolic syndrome and cancer
Garay-Sevilla, Ma. Eugenia; Gomez-Ojeda, Armando; González-Bonet, Ileana; Luevano Contreras, Claudia; Rojas, Armando (2021)Far beyond the compelling proofs supporting that the metabolic syndrome represents a risk factor for diabetes and cardiovascular diseases, a growing body of evidence suggests that it is also a risk factor for different ...
-
Dermal collagen stabilization by polyphenols and spray drying as an encapsulation strategy
Añazco-Oyarzún, Carolina; Rojas, Armando ; González-Bonet, Ileana; Castro, Maite A.; Robert, Paz; Oyarzun-Ampuero, Felipe (2018)Collagen, the most abundant component in mammalian tissues, has a crucial impact at skin level. Both promotion and maintenance of cross-linked collagen at the skin are critical to sustain the functionality and appearance ...
-
Extracellular matrix glycation and receptor for advanced glycation end-products activation: A missing piece in the puzzle of the association between diabetes and cancer
A growing body of epidemiologic evidence suggests that people with diabetes are at a significantly higher risk of many forms of cancer. However, the molecular mechanisms underlying this association are not fully understood. ...
-
Gastric tumor microenvironment
A compelling body of evidence has demonstrated that gastric cancer has a very particular tumor microenvironment, a signature very suitable to promote tumor progression and metastasis. Recent investigations have provided ...
-
Healthy eating recommendations: Good for reducing dietary contribution to the body’s advanced glycation/lipoxidation end products pool?
Del Castillo, María Dolores; Iriondo-DeHond, Amaia; Iriondo-DeHond, Maite; González-Bonet, Ileana; Medrano, Alejandra; Filip, Rosana; Uribarri, Jaime (2021)The present review aims to give dietary recommendations to reduce the occurrence of the Maillard reaction in foods and in vivo to reduce the body’s advanced glycation/lipoxidation end products (AGE/ALE) pool. A healthy ...
-
Helicobacter pylori infection and lung cancer: New insights and future challenges
Helicobacter pylori (H. pylori) is the causative agent of chronic gastritis and peptic ulcer diseases and is an important risk factor for the development functional dyspepsia, peptic ulceration, gastric adenocarcinoma and ...
-
HMGB1 enhances the protumoral activities of M2 macrophages by a RAGE-dependent mechanism
Rojas, Armando ; Delgado-López, Fernando; Pérez-Castro, Ramón; González-Bonet, Ileana; Romero, Jacqueline; Rojas, Israel; Araya, Paulina; Morales-Mejías, Erik; Llano, Jorge; Añazco-Oyarzún, Carolina (2016)The monocyte-macrophage lineage shows a high degree of diversity and plasticity. Once they infiltrate tissues,they may acquire two main functional phenotypes, being known as the classically activated type 1 macrophages ...
-
Inhibition of RAGE Axis signaling: A pharmacological challenge
The Receptor for Advanced Glycation End Products (RAGE) is an important cell surface receptor, which belongs to the IgG super family and is now considered as a pattern recognition receptor. Because of its relevance in many ...
-
Lysyl oxidase isoforms in gastric cancer
Delgado-López, Fernando; Araya, Paulina; González-Bonet, Ileana; Morales-Mejías, Erik; Pérez-Castro, Ramón; Romero, Jacqueline; Rojas, Armando ; Añazco-Oyarzún, Carolina (2016)Gastric cancer (GC) is the fifth most frequent cancer in the world and shows the highest incidence in Latin America and Asia. An increasing amount of evidence demonstrates that lysyl oxidase isoforms, a group of extracellular ...
-
Pathogenic potential of Helicobacter pylori strains can explain differences in H. pylori associated diseases rates from Chile and Cuba
González-Bonet, Ileana; González, Lidice; Rojas, Armando ; Rodríguez, Boris L.; Romero, Jacqueline; Reyes, Orlando; Morales, Erik; Alonso, Jordis; Pérez-Castro, Ramón; Sabatier, Carlos A.; Valdés, Eliana; Torres, Linio E.; Cofré, Cecilia (2019)Background: The prevalence of Helicobacter pylori-related diseases varies geographically and it is partially determined by the virulence of the circulating strains. Cuba and Chile exhibit different gastric cancer rates, ...
-
Patrón EPIYA en cepas de Helicobacter pylori CagA positivas en pacientes del Hospital Regional de Talca
González-Bonet, Ileana; Romero-Elias, María; Morales-Mejías, Erik; Valdez-Moyano, Eliana; Cofré-Loyola, Cecilia; Manques-Maldonado, Belarmino; Rojas, Armando (2017)Background: The clinical outcome of Helicobacter pylori (H. pylori) infection has been related to the presence of CagA protein. This protein is highly polymorphic and its oncogenic ability depends on the number and type ...
-
Receptor for advanced glycation end-products axis and coronavirus disease 2019 in inflammatory bowel diseases: A dangerous liaison?
Rojas, Armando ; Schneider, Iván; Lindner-Sanhueza, Cristian; González-Bonet, Ileana; Morales, Miguel A. (2021)Compelling evidence supports the crucial role of the receptor for advanced glycation end-products (RAGE) axis activation in many clinical entities. Since the beginning of the coronavirus disease 2019 pandemic, there is an ...
-
RID: Evaluation of the possible inhibiting effect of the proinflammatory signaling induced by TNF-α through NF-κβ and AP-1 in two cell lines of breast cancer
Monsalve, Francisco A.; Rojas, Armando ; González-Bonet, Ileana; Pérez-Castro, Ramón; Añazco-Oyarzún, Carolina; Romero, Jacqueline; Araya, Paulina; Santos, Leonardo S.; Delgado-López, Fernando (2020)Receptor internalization and degradation (RID), is a transmembrane protein coded within the E3 region expression cassette of adenoviruses. RID downregulates the cell surface expression of epidermal growth factor receptor ...
-
SARS-CoV-2-mediated inflammatory response in lungs: should we look at rage?
The novel coronavirus disease (COVID-19) pandemic is placing significant strains on health systems, scientific communities, essential public services, and economies all over the world. In this context, the world´s scientific ...
-
Skewed signaling through the receptor for advanced glycation end-products alters the proinflammatory profile of tumor-associated macrophages
Rojas, Armando ; Araya, Paulina; Romero, Jacqueline; Delgado-López, Fernando; González-Bonet, Ileana; Añazco-Oyarzún, Carolina; Pérez-Castro, Ramón (2018)Tumors are complex tissues composed of variable amounts of both non-cellular components (matrix proteins) and a multitude of stromal cell types, which are under an active cross-talk with tumor cells. Tumor-associated ...
-
The emerging role of the receptor for advanced glycation end products on innate immunity
Rojas, Armando ; Pérez-Castro, Ramón; González-Bonet, Ileana; Delgado-López, Fernando; Romero, Jacqueline; Rojas, Israel (2014)Cells from innate immune system are activated by the engagement of germ-line encoded patternrecognition receptors (PRRs) in response to the microbial insult. These receptors are able to recognize either the presence of ...
-
The immunobiology of the receptor of advanced glycation end-products: Trends and challenges
González-Bonet, Ileana; Romero, Jacqueline; Rodríguez, Boris L.; Pérez-Castro, Ramón; Rojas, Armando (2013)Pattern-recognition receptors have been highly conserved in evolution. They recognize danger signals including both pathogen- and damage-associated molecular patterns, also known as alarmins. Several signaling pathways ...