Listar por materia "Inflammation"
Mostrando publicaciones 1-12 de 12
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Adipose tissue macrophages as a therapeutic target in obesity-associated diseases
(2021)Obesity is an increasing problem in developed and developing countries. Individuals with obesity have a higher risk of several diseases, such as cardiovascular disease, increased risk of insulin resistance, type 2 diabetes, ...
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Advanced-glycation end-products axis: A contributor to the risk of severe illness from COVID-19 in diabetes patients
(2021)Compelling pieces of evidence derived from both clinical and experimental research has demonstrated the crucial role of the receptor for advanced-glycation end-products (RAGE) in orchestrating a plethora of proinflammatory ...
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Body adiposity partially mediates the association between fto rs9939609 and lower adiponectin levels in chilean children
(2023)Children carrying the minor allele ‘A’ at the fat mass and obesity-associated protein (FTO) gene have higher obesity prevalence. We examined the link between FTO rs9939609 polymorphism and plasma adiponectin and the ...
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C-reactive protein partially mediates the inverse association between coffee consumption and risk of type 2 diabetes: the uk biobank and the Rotterdam study cohorts
(2023)Background Coffee is among the most consumed beverages worldwide. Coffee consumption has been associated with lower risk of type 2 diabetes mellitus (T2D), but underlying mechanisms are not well understood. We aimed to ...
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Contribution of RAGE axis activation to the association between metabolic syndrome and cancer
(2021)Far beyond the compelling proofs supporting that the metabolic syndrome represents a risk factor for diabetes and cardiovascular diseases, a growing body of evidence suggests that it is also a risk factor for different ...
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Dietary advanced glycation end products and their role in health and disease
(2015)Over the past 2 decades there has been increasing evidence supporting an important contribution from food-derived advanced glycation end products (AGEs) to the body pool of AGEs and therefore increased oxidative stress and ...
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Michael acceptor containing drugs are a novel class of 5-lipoxygenase inhibitor targeting the surface cysteines C416 and C418
(2017)Recently, we published that nitro-fatty acids (NFA) are potent electrophilic molecules which inhibit 5-lipoxygenase (5-LO) by interacting catalytically with cysteine residues next to a substrate entry channel. The ...
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Receptor for advanced glycation end-products axis and coronavirus disease 2019 in inflammatory bowel diseases: A dangerous liaison?
(2021)Compelling evidence supports the crucial role of the receptor for advanced glycation end-products (RAGE) axis activation in many clinical entities. Since the beginning of the coronavirus disease 2019 pandemic, there is an ...
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RGD-binding integrins and TGF-β in SARS-CoV-2 infections – novel targets to treat COVID-19 patients?
(2021)The new coronavirus SARS-CoV-2 is a global pandemic and a severe public health crisis. SARS-CoV-2 is highly contagious and shows high mortality rates, especially in elderly and patients with pre-existing medical conditions. ...
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SARS-CoV-2-mediated inflammatory response in lungs: should we look at rage?
(2020)The novel coronavirus disease (COVID-19) pandemic is placing significant strains on health systems, scientific communities, essential public services, and economies all over the world. In this context, the world´s scientific ...
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The immunobiology of the receptor of advanced glycation end-products: Trends and challenges
(2013)Pattern-recognition receptors have been highly conserved in evolution. They recognize danger signals including both pathogen- and damage-associated molecular patterns, also known as alarmins. Several signaling pathways ...
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The receptor for advanced glycation end-products: A complex signaling scenario for a promiscuous receptor
(2013)Firstly described in 1992, the receptor for advanced glycation end-products has attracted increasing attention due to its diverse ligand repertoire and involvement in several pathophysiological processes associated with ...