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Mostrando publicaciones 1-20 de 38
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Abbreviated score to assess adherence to the 2018 WCRF/AICR cancer prevention recommendations and risk of cancer in the UK biobank
Malcomson, Fiona C.; Parra‑Soto, Solange; Ho, Frederick; Celis-Morales, Carlos; Sharp, Linda; Mathers, John (2024)Background: The World Cancer Research Fund (WCRF)/American Institute for Cancer Research (AICR) Cancer Prevention Recommendations are lifestyle-based guidelines which aim to reduce cancer risk. This study investigated, ...
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Adherence to the 2018 World Cancer Research Fund (WCRF)/American Institute for Cancer Research (AICR) Cancer Prevention Recommendations and risk of 14 lifestyle-related cancers in the UK Biobank prospective cohort study
Malcomson, Fiona C.; Parra‑Soto, Solange; Ho, Frederick; Lu, Liya; Celis-Morales, Carlos; Sharp, Linda; Mathers, John (2023)Background The World Cancer Research Fund (WCRF)/American Institute for Cancer Research (AICR) Cancer Prevention Recommendations are lifestyle-based recommendations which aim to reduce cancer risk. This study investigated ...
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Alzheimer's disease susceptibility gene Apolipoprotein E (APOE) and blood biomarkers in UK Biobank (N = 395,769)
Ferguson, Amy C.; Tank, Rachana; Lyall, Laura M.; Ward, Joey; Celis-Morales, Carlos; Strawbridge, Rona; Ho, Frederick; Whelan, Christopher D.; Gill, Jason M.R.; Welsh, Paul; Anderson, Jana J.; Mark, Patrick B.; Mackay, Daniel; Smith, Daniel J.; Pell, J.P.; Cavanagh, Jonathan; Sattar, Naveed; Lyall, Donald (2020)Background: Alzheimer's disease (AD) is a neurodegenerative condition where the underlying etiology is still unclear. Investigating the potential influence of apolipoprotein E (APOE), a major genetic risk factor, on common ...
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An opportunity for prevention: associations between the life's essential 8 score and cardiovascular incidence using prospective data from uk biobank
Petermann-Rocha, Fanny; Deo, Salil; Celis-Morales, Carlos; Ho, Frederick; Bahuguna, Pankaj; McAllister, David; Sattar, Naveed; Pell, J.P. (2023)To investigate the association between the Life's Essential 8 (LE8) score and the incidence of four cardiovascular outcomes (ischemic heart disease, myocardial infarction, stroke, and heart failure [HF]) – separately and ...
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Are people with metabolically healthy obesity really healthy? A prospective cohort study of 381,363 UK Biobank participants
Zhou, Ziyi; Macpherson, John; Gray, S.R.; Gill, Jason M.R.; Welsh, Paul; Celis-Morales, Carlos; Sattar, Naveed; Pell, J.P.; Ho, Frederick (2021)Aims/hypothesis: People with obesity and a normal metabolic profile are sometimes referred to as having ‘metabolically healthy obesity’ (MHO). However, whether this group of individuals are actually ‘healthy’ is uncertain. ...
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Association between being breastfed and cardiovascular disease: a population cohort study of 320 249 participants
Nakada, Shinya; Ho, Frederick; Celis-Morales, Carlos; Pell, J.P. (2023)Background Being breastfed is associated with lower cardiovascular risk factors but, to date, no studies have demonstrated a protective effect on cardiovascular disease (CVD). This study aims to address the limitations of ...
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Association between device-measured physical activity and incident heart failure: a prospective cohort study of 94 739 uk biobank participants
Ho, Frederick; Zhou, Ziyi; Petermann-Rocha, Fanny; Para-Soto, Solange; Boonpor, Jirapitcha; Welsh, Paul; Gill, Jason M.R.; Gray, S.R.; Sattar, Naveed; Pell, J.P.; Celis-Morales, Carlos (2022)Background: Studies of objectively measured physical activity (PA) have investigated acute cardiovascular outcomes but not heart failure (HF), an emerging chronic condition. This study aimed to investigate the dose-response ...
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Association between menstrual cycle phase and metabolites in healthy, regularly menstruating women in UK Biobank, and effect modification by inflammatory markers and risk factors for metabolic disease
MacGregor, Kirstin A.; Ho, Frederick; Celis-Morales, Carlos; Pell, J.P.; Gallagher, Iain J.; Moran, Colin N. (2023)Background Preliminary evidence demonstrates some parameters of metabolic control, including glycaemic control, lipid control and insulin resistance, vary across the menstrual cycle. However, the literature is inconsistent, ...
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Association of sarcopenia with incident osteoporosis: a prospective study of 168,682 UK biobank participants
Petermann-Rocha, Fanny; Ferguson, Lyn D.; Gray, S.R.; Rodríguez-Gómez, Irene; Sattar, Naveed; Siebert, Stefan; Ho, Frederick; Pell, J.P.; Celis-Morales, Carlos (2021)Background: Sarcopenia often co-occurs with osteoporosis in cross-sectional studies. However, this association has rarely been studied in prospective studies. This study aimed to investigate the association between sarcopenia ...
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Associations and predictive performance of 11 anthropometric measures with incident type 2 diabetes: a prospective cohort study from the UK Biobank
Boonpor, Jirapitcha; Parra‑Soto, Solange; Talebi, Atefeh; Zhou, Ziyi; Carrasco-Marin, Fernanda; Petermann-Rocha, Fanny; Welsh, Paul; Pell, J.P.; Sattar, Naveed; Gill, Jason M.R.; Gray, S.R.; Celis-Morales, Carlos; Ho, Frederick (2023)Objective The study aim was to investigate associations of 11 anthropometric measures with incident type 2 diabetes and compare their predictive performance. Methods This prospective cohort study included 161,127 White ...
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Associations between an inflammatory diet index and severe non-alcoholic fatty liver disease: a prospective study of 171,544 UK Biobank participants
Petermann-Rocha, Fanny; Wirth, Michael D.; Boonpor, Jirapitcha; Parra‑Soto, Solange; Zhou, Ziyi; Mathers, John; Livingstone, Katherine M.; Forrest, Ewan; Pell, J.P.; Ho, Frederick; Hébert, James R; Celis-Morales, Carlos (2023)Background Although non-alcoholic fatty liver disease (NAFLD) is linked to infammation, whether an infammatory diet increases the risk of NAFLD is unclear. This study aimed to examine the association between the Energy-adjusted ...
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Associations between diet and handgrip strength: a cross-sectional study from UK biobank
Gedmantaite, A.; Celis-Morales, Carlos; Ho, Frederick; Pell, J.P.; Ratkevicius, A.; Gray, S.R. (2020)The aim of the current study was to investigate the association between diet and handgrip strength. The current study included 68,002 participants (age 63.8 ± 2.7 years, 50.3% women, 49.7% men) from UK Biobank. Diet and ...
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Associations between grip strength and incident type 2 diabetes: findings from the UK Biobank prospective cohort study
Boonpor, Jirapitcha; Parra, Solange; Petermann-Rocha, Fanny; Ferrari, Gerson Luis de Moraes; Welsh, Paul; Pell, J.P.; Sattar, Naveed; Gill, Jason M.R.; Ho, Frederick; Gray, S.R.; Celis-Morales, Carlos (2021)Introduction: Grip strength has been associated with chronic diseases and mortality. However, current evidence of the association between grip strength and incident type 2 diabetes mellitus (T2DM) is controversial. The aim ...
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Associations between physical frailty and dementia incidence: a prospective study from UK Biobank
Petermann-Rocha, Fanny; Lyall, Donald; Gray, S.R.; Esteban-Cornejo, Irene; Quinn, Terence J.; Ho, Frederick; Pell, J.P.; Celis-Morales, Carlos (2020)Background: Dementia is associated with a high burden of dependency and disability. Physical frailty (hereafter referred to as frailty) is a multisystem dysregulation that has been identified as a risk factor for dementia. ...
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Associations of fat and carbohydrate intake with cardiovascular disease and mortality: prospective cohort study of UK Biobank participants
Ho, Frederick; Gray, S.R.; Welsh, Paul; Petermann-Rocha, Fanny; Foster, Hamish M. E.; Waddell, Heather; Anderson, Jana J.; Lyall, Donald; Sattar, Naveed; Gill, Jason M.R.; Mathers, John; Pell, J.P.; Celis-Morales, Carlos (2020)Objective: To investigate the association of macronutrient intake with all cause mortality and cardiovascular disease (CVD), and the implications for dietary advice. Design: Prospective population based study. Setting: ...
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Associations of six adiposity-related markers with incidence and mortality from 24 cancers—findings from the UK Biobank prospective cohort study
Parra, Solange; Cowley, Emma; Rezende, Leandro F. M.; Ferreccio, Catterina; Mathers, John; Pell, J.P.; Ho, Frederick; Celis-Morales, Carlos (2021)Background: Adiposity is a strong risk factor for cancer incidence and mortality. However, most of the evidence available has focused on body mass index (BMI) as a marker of adiposity. There is limited evidence on relationships ...
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Biomarkers profile of people with sarcopenia: a cross-sectional analysis from UK Biobank
Petermann-Rocha, Fanny; Gray, S.R.; Pell, J.P.; Celis-Morales, Carlos; Ho, Frederick (2020)Objective: This study aimed to characterize the biomarker profile of sarcopenic vs nonsarcopenic men and women, using the current European Working Group on Sarcopenia in Older People (EWGSOP2) definition in the UK Biobank ...
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C-reactive protein partially mediates the inverse association between coffee consumption and risk of type 2 diabetes: the uk biobank and the Rotterdam study cohorts
Ochoa-Rosales, Carolina; van der Schaft, Niels; Braun, Kim V.E.; Arfan Ikram, M.; Celis-Morales, Carlos; Voortman, Trudy; Ho, Frederick; Petermann-Rocha, Fanny; Ahmadizar, Fariba; Kavousi, Maryam; Pell, J.P. (2023)Background Coffee is among the most consumed beverages worldwide. Coffee consumption has been associated with lower risk of type 2 diabetes mellitus (T2D), but underlying mechanisms are not well understood. We aimed to ...
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Changes over 15 years in the contribution of adiposity and smoking to deaths in England and Scotland
Ho, Frederick; Celis-Morales, Carlos; Petermann-Rocha, Fanny; Parra, Solange; Lewsey, James; Mackay, Daniel; Pell, J.P. (2021)Background: For many years smoking has been the major threat to public health in developed countries. However, smoking prevalence has declined over a period when adiposity has increased. The aim of this study was to determine ...
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Child maltreatment and cardiovascular disease: quantifying mediation pathways using UK biobank
Ho, Frederick; Celis-Morales, Carlos; Gray, S.R.; Petermann-Rocha, Fanny; Lyall, Donald; Mackay, Daniel; Sattar, Naveed; Minnis, Helen; Pell, J.P. (2020)Background: Child maltreatment is associated with cardiovascular disease (CVD), but mediation pathways have not been fully elucidated. The aim of the current study was to determine and quantify the underlying pathways ...