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Cross-talk between platelet and tumor microenvironment: Role of multiligand/RAGE axis in platelet activation
(2016)
While platelets are well known to play a central role in hemostasis and thrombosis, there is emerging experimental evidence to suggest that they also mediate tumor cell growth, angiogenesis and metastasis. The receptor for ...
NF-κB signaling pathway as target for antiplatelet activity
(2016)
In different nucleated cells, NF-κB has long been considered a prototypical proinflammatory signaling pathway with the expression of proinflammatory genes.
Although platelets lack a nucleus, a number of functional ...
Role of multiligand/RAGE axis in platelet activation
(2014)
In the context of plaque progression, platelet hyperactivity associated with hyperlipidemia contributes to the development of a pro-thrombotic state. In this context, it has been demonstrated that advanced glycation end ...
Chlorogenic acid inhibits human platelet activation and thrombus formation
(2014)
Background: Chlorogenic acid is a potent phenolic antioxidant. However, its effect on platelet aggregation, a critical factor
in arterial thrombosis, remains unclear. Consequently, chlorogenic acid-action mechanisms in ...
The immunobiology of the receptor of advanced glycation end-products: Trends and challenges
(2013)
Pattern-recognition receptors have been highly conserved in evolution. They recognize danger signals including both pathogen- and damage-associated molecular patterns, also known as alarmins. Several signaling pathways ...
M2 macrophages do not fly into a “RAGE”
(2017)
Tumor-associated macrophages (TAMs) are key elements in orchestrating host responses inside tumor stroma. This population may undergo a polarized activation process, thus rendering a heterogeneous spectrum of phenotypes, ...
Dermal collagen stabilization by polyphenols and spray drying as an encapsulation strategy
(2018)
Collagen, the most abundant component in mammalian tissues, has a crucial impact at skin level. Both promotion and maintenance of cross-linked collagen at the skin are critical to sustain the functionality and appearance ...
The receptor for advanced glycation end-products: A complex signaling scenario for a promiscuous receptor
(2013)
Firstly described in 1992, the receptor for advanced glycation end-products has attracted increasing attention due to its diverse ligand repertoire and involvement in several pathophysiological processes associated with ...
Is ozone pre-conditioning effect linked to Nrf2/EpRE activation pathway in vivo? A preliminary result
(2014)
The present preliminary study has been focused on verifying whether ozone preconditioning may be linked to Nrf2/EpRE (nuclear factor erythroid 2/electrophile-responsive element) activation pathway in vivo. Healthy volunteers ...