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iNOS activation regulates b-catenin association with its partners in endothelial cells
(2012)
Background: Signals that disrupt b-catenin association to cadherins may influence the translocation of b-catenin to the
nucleus to regulate transcription. Post-translational modification of proteins is a signalling event ...
Extracellular matrix glycation and receptor for advanced glycation end-products activation: A missing piece in the puzzle of the association between diabetes and cancer
(2018)
A growing body of epidemiologic evidence suggests that people with diabetes are at a significantly higher risk of many forms of cancer. However, the molecular mechanisms underlying this association are not fully understood. ...
Inhibition of RAGE Axis signaling: A pharmacological challenge
(2019)
The Receptor for Advanced Glycation End Products (RAGE) is an important cell surface receptor, which belongs to the IgG super family and is now considered as a pattern recognition receptor. Because of its relevance in many ...
Helicobacter pylori infection and lung cancer: New insights and future challenges
(2018)
Helicobacter pylori (H. pylori) is the causative agent of chronic gastritis and peptic ulcer diseases and is an important risk factor for the development functional dyspepsia, peptic ulceration, gastric adenocarcinoma and ...
The potential role of dietary advanced glycation endproducts in the development of chronic non-infectious diseases: A narrative review
(2020)
Increasing clinical and experimental evidence accumulated during the past few decades supports an important role for dietary advanced glycation endproducts (AGE) in the pathogenesis of many chronic non-infectious diseases, ...
Contribution of RAGE axis activation to the association between metabolic syndrome and cancer
(2021)
Far beyond the compelling proofs supporting that the metabolic syndrome represents a risk factor for diabetes and cardiovascular diseases, a growing body of evidence suggests that it is also a risk factor for different ...
Advanced-glycation end-products axis: A contributor to the risk of severe illness from COVID-19 in diabetes patients
(2021)
Compelling pieces of evidence derived from both clinical and experimental research has demonstrated the crucial role of the receptor for advanced-glycation end-products (RAGE) in orchestrating a plethora of proinflammatory ...
Gallstones, body mass index, C-reactive protein, and gallbladder cancer: Mendelian randomization analysis of Chilean and European genotype data
(2021)
Background and Aims: Gallbladder cancer (GBC) is a neglected disease with substantial geographical variability: Chile shows the highest incidence worldwide, while GBC is relatively rare in Europe. Here, we investigate the ...